TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells.

@article{Nakae2007TIM1AT,
  title={TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells.},
  author={Susumu Nakae and Motoyasu Iikura and Hajime Suto and Hisaya Akiba and Dale T. Umetsu and Rosemarie H. Dekruyff and Hirohisa Saito and Stephen J. Galli},
  journal={Blood},
  year={2007},
  volume={110 7},
  pages={2565-8}
}
Members of the T-cell immunoglobulin- and mucin-domain-containing molecule (TIM) family have roles in T-cell-mediated immune responses. TIM-1 and TIM-2 are predominantly expressed on T helper type 2 (Th2) cells, whereas TIM-3 is preferentially expressed on Th1 and Th17 cells. We found that TIM-1 and TIM-3, but neither TIM-2 nor TIM-4, were constitutively expressed on mouse peritoneal mast cells and bone marrow-derived cultured mast cells (BMCMCs). After IgE + Ag stimulation, TIM-1 expression… CONTINUE READING