TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis

@article{Bensaad2006TIGARAP,
  title={TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis},
  author={K. Bensaad and A. Tsuruta and M. Selak and M. Vidal and K. Nakano and R. Bartrons and E. Gottlieb and K. Vousden},
  journal={Cell},
  year={2006},
  volume={126},
  pages={107-120}
}
The p53 tumor-suppressor protein prevents cancer development through various mechanisms, including the induction of cell-cycle arrest, apoptosis, and the maintenance of genome stability. We have identified a p53-inducible gene named TIGAR (TP53-induced glycolysis and apoptosis regulator). TIGAR expression lowered fructose-2,6-bisphosphate levels in cells, resulting in an inhibition of glycolysis and an overall decrease in intracellular reactive oxygen species (ROS) levels. These functions of… Expand
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TP53 induced glycolysis and apoptosis regulator (TIGAR) knockdown results in radiosensitization of glioma cells.
TLDR
TIGAR abrogation provides a novel adjunctive therapeutic strategy against glial tumors by increasing radiation-induced cell impairment, thus allowing the use of lower radiotherapeutic doses. Expand
TP53-induced glycolysis and apoptosis regulator promotes proliferation and invasiveness of nasopharyngeal carcinoma cells
TLDR
It is revealed that TIGAR overexpression led to increased cellular growth, NADPH production and invasiveness, and the maintenance of a mesenchymal phenotype, in NPC tissues. Expand
TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Is Upregulated in Lymphocytes Stimulated with Concanavalin A
TLDR
It is demonstrated here that TIGAR is upregulated in stimulated human lymphocytes through the PI3K/AKT signaling pathway, which contributes to the redirection of the carbon flux to the PPP. Expand
TIGAR has a dual role in cancer cell survival through regulating apoptosis and autophagy.
TLDR
It is revealed that TIGAR inhibits both apoptosis and autophagy, resulting in a dual impact on tumor cell survival in response to tumor chemotherapy, which is correlated with reduced tumorigenicity and increased chemosensitivity in mouse xenograft tumor assays. Expand
The complexity of p53-mediated metabolic regulation in tumor suppression.
TLDR
The roles of p53 in the regulation of glucose, lipid, amino acid, nucleotide, iron metabolism, and ROS production are summarized and the mechanisms underlying p53-mediated ferroptosis, AKT/mTOR signaling as well as autophagy are highlighted. Expand
Regulation of glucose metabolism by p53: Emerging new roles for the tumor suppressor
TLDR
The importance of p53-mediated regulation of glycolysis and OXPHOS and its relation with the tumor suppressor function of p 53 is elucidated and the role of p52 in regulation of aging via its transcriptional control of cellular metabolism is established. Expand
p53- and p73-independent activation of TIGAR expression in vivo
TIGAR (TP53-induced glycolysis and apoptosis regulator) functions as a fructose-2,6-bisphosphatase and its expression results in a dampening of the glycolytic pathway, while increasing antioxidant… Expand
TIGAR Promotes Tumorigenesis and Protects Tumor Cells From Oxidative and Metabolic Stresses in Gastric Cancer
TLDR
TIGAR exhibits oncogenic features in GC, which can be evaluated as a target for intervention in the treatment of GC, and is determined by utilizing shRNA-mediated knockdown experiments. Expand
Dynamic roles of p53-mediated metabolic activities in ROS-induced stress responses
TLDR
It is reported that wild type p53 can induce both apoptosis and ferroptosis upon reactive oxygen species (ROS)-induced stress, and it is demonstrated that p53's functional N-terminal domain is required for its capacity to regulate oxidative stress responses and ferryptosis. Expand
Knockdown of TIGAR by RNA interference induces apoptosis and autophagy in HepG2 hepatocellular carcinoma cells.
TLDR
These data provide the first evidence that targeted silencing of TIGAR induces apoptotic and autophagic cell death in HepG2 cells, and raise hope for the future successful application of TigAR siRNA in patients with hepatocellular carcinoma (HCC). Expand
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