TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis
@article{Bensaad2006TIGARAP, title={TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis}, author={Karim Bensaad and Atsushi Tsuruta and Mary A. Selak and Miquel Vidal and Katsunori Nakano and Ramon Bartrons and Eyal Gottlieb and Karen H. Vousden}, journal={Cell}, year={2006}, volume={126}, pages={107-120} }
1,737 Citations
TP53 induced glycolysis and apoptosis regulator (TIGAR) knockdown results in radiosensitization of glioma cells.
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- 2011
TP53-induced glycolysis and apoptosis regulator promotes proliferation and invasiveness of nasopharyngeal carcinoma cells
- BiologyOncology letters
- 2015
It is revealed that TIGAR overexpression led to increased cellular growth, NADPH production and invasiveness, and the maintenance of a mesenchymal phenotype, in NPC tissues.
TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Is Upregulated in Lymphocytes Stimulated with Concanavalin A
- BiologyInternational journal of molecular sciences
- 2021
It is demonstrated here that TIGAR is upregulated in stimulated human lymphocytes through the PI3K/AKT signaling pathway, which contributes to the redirection of the carbon flux to the PPP.
The complexity of p53-mediated metabolic regulation in tumor suppression.
- Biology, ChemistrySeminars in cancer biology
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TIGAR has a dual role in cancer cell survival through regulating apoptosis and autophagy.
- Biology, MedicineCancer research
- 2014
It is revealed that TIGAR inhibits both apoptosis and autophagy, resulting in a dual impact on tumor cell survival in response to tumor chemotherapy, which is correlated with reduced tumorigenicity and increased chemosensitivity in mouse xenograft tumor assays.
Regulation of glucose metabolism by p53: Emerging new roles for the tumor suppressor
- BiologyOncotarget
- 2011
The importance of p53-mediated regulation of glycolysis and OXPHOS and its relation with the tumor suppressor function of p 53 is elucidated and the role of p52 in regulation of aging via its transcriptional control of cellular metabolism is established.
p53- and p73-independent activation of TIGAR expression in vivo
- BiologyCell Death and Disease
- 2015
TIGAR (TP53-induced glycolysis and apoptosis regulator) functions as a fructose-2,6-bisphosphatase and its expression results in a dampening of the glycolytic pathway, while increasing antioxidant…
TIGAR Promotes Tumorigenesis and Protects Tumor Cells From Oxidative and Metabolic Stresses in Gastric Cancer
- BiologyFront. Oncol.
- 2019
TIGAR exhibits oncogenic features in GC, which can be evaluated as a target for intervention in the treatment of GC, and is determined by utilizing shRNA-mediated knockdown experiments.
Dynamic roles of p53-mediated metabolic activities in ROS-induced stress responses
- BiologyCell cycle
- 2015
It is reported that wild type p53 can induce both apoptosis and ferroptosis upon reactive oxygen species (ROS)-induced stress, and it is demonstrated that p53's functional N-terminal domain is required for its capacity to regulate oxidative stress responses and ferryptosis.
Knockdown of TIGAR by RNA interference induces apoptosis and autophagy in HepG2 hepatocellular carcinoma cells.
- Biology, MedicineBiochemical and biophysical research communications
- 2013
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