TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis

  title={TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis},
  author={Karim Bensaad and Atsushi Tsuruta and Mary A. Selak and Miquel Vidal and Katsunori Nakano and Ramon Bartrons and Eyal Gottlieb and Karen H. Vousden},

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It is shown that p53 protects the genome from oxidation by reactive oxygen species (ROS), a major cause of DNA damage and genetic instability, and relatively low levels of p53 are sufficient for upregulation of several genes with antioxidant products, which is associated with a decrease in intracellular ROS.
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