TIEG-null mice display an osteopenic gender-specific phenotype.

@article{Hawse2008TIEGnullMD,
  title={TIEG-null mice display an osteopenic gender-specific phenotype.},
  author={John R Hawse and Urszula T. Iwaniec and Sabine Bensamoun and David G. Monroe and Kenneth D Peters and Brice Ilharreborde and Nalini M. Rajamannan and Merry Jo Oursler and Russell T. Turner and Thomas C. Spelsberg and Malayannan Subramaniam},
  journal={Bone},
  year={2008},
  volume={42 6},
  pages={1025-31}
}
TGFbeta inducible early gene-1 (TIEG) was originally cloned from human osteoblasts (OB) and has been shown to play an important role in TGFbeta/Smad signaling, regulation of gene expression and OB growth and differentiation. To better understand the biological role of TIEG in the skeleton, we have generated congenic TIEG-null (TIEG(-/-)) mice in a pure… CONTINUE READING