TIC10/ONC201 synergizes with Bcl-2/Bcl-xL inhibition in glioblastoma by suppression of Mcl-1 and its binding partners in vitro and in vivo

@inproceedings{KarpelMassler2015TIC10ONC201SW,
  title={TIC10/ONC201 synergizes with Bcl-2/Bcl-xL inhibition in glioblastoma by suppression of Mcl-1 and its binding partners in vitro and in vivo},
  author={Georg Karpel-Massler and Ma{\"i}mouna B{\^a} and Chang Shu and M. Halatsch and Mike-Andrew Westhoff and Jeffrey N. Bruce and Peter Canoll and Markus David Siegelin},
  booktitle={Oncotarget},
  year={2015}
}
Glioblastoma is the most frequent primary brain tumor in adults. Current therapeutic options are sparse and the prognosis of patients suffering from this disease is grim. Abundance in intratumoral heterogeneity among different deregulated signaling pathways is a hallmark of glioblastoma and likely accounts for its recurrence and resistance to treatment. Glioblastomas harbor a plethora of deregulated pathways driving tumor formation and growth. In this study, we show that TIC10/ONC201, a… CONTINUE READING

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