TI-CE high-dose chemotherapy for patients with previously treated germ cell tumors: results and prognostic factor analysis.

@article{Feldman2010TICEHC,
  title={TI-CE high-dose chemotherapy for patients with previously treated germ cell tumors: results and prognostic factor analysis.},
  author={Darren R Feldman and Joel Sheinfeld and Dean F Bajorin and Patricia M Fischer and Stefan Turkula and Nicole M. Ishill and Sujata Patil and Manjit Bains and Lilian M Reich and George J. Bosl and Robert J Motzer},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2010},
  volume={28 10},
  pages={1706-13}
}
PURPOSE We previously reported a dose-finding and phase II trial of the TI-CE regimen (paclitaxel [T] plus ifosfamide [I] followed by high-dose carboplatin [C] plus etoposide [E] with stem-cell support) in germ cell tumor (GCT) patients predicted to have a poor prognosis with conventional-dose salvage therapy. We now report the efficacy of TI-CE with prognostic factors for disease-free survival (DFS) and overall survival (OS) in our full data set of 107 patients. PATIENTS AND METHODS Eligible… CONTINUE READING
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Germcell tumors

  • J Shamash, J Stebbing, T Powles
  • N Engl J Med
  • 2007

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