THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels.

@article{Rajan2001THIK1AT,
  title={THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels.},
  author={Sindhu K. Rajan and Erhard Wischmeyer and Christine Karschin and Regina Preisig-m{\"u}ller and K. H. Grzeschik and J{\"u}rgen Daut and Andreas Karschin and Christian Derst},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 10},
  pages={
          7302-11
        }
}
Two cDNAs encoding novel K(+) channels, THIK-1 and THIK-2 (tandem pore domain halothane inhibited K(+) channel), were isolated from rat brain. The proteins of 405 and 430 amino acids were 58% identical to each other. Homology analysis showed that the novel channels form a separate subfamily among tandem pore domain K(+) channels. The genes of the human orthologs were identified as human genomic data base entries. They possess one intron each and were assigned to chromosomal region 14q24.1-14q24… CONTINUE READING
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