THIAMINE ANTAGONISTS

@article{Rogers1962THIAMINEA,
  title={THIAMINE ANTAGONISTS},
  author={E. Rogers},
  journal={Annals of the New York Academy of Sciences},
  year={1962},
  volume={98}
}
  • E. Rogers
  • Published 1962
  • Medicine
  • Annals of the New York Academy of Sciences
A thiamine antagonist may be defined as a compound that can compete with Antagonists, in First, antagonists may serve as experimental A second possibility, which seldom materialIn the case of thiamine thiamine or thiamine derivatives in enzymatic reactions. general, have two possible uses. tools for the biological sciences. izes, is chemotherapeutic or pharmacological utility. we are fortunate in having antagonists of both classes. 
1 Citations

Topics from this paper

References

SHOWING 1-10 OF 72 REFERENCES
A New Antagonist of Thiamine
TLDR
Thiamine analogue derived from I is synthesized, which would differ from thiamine only in the nature of the 2-substituent, and which, on the basis of a recently proposed mechanism of thienine action4, might be expected to have thiamines activity. Expand
An enzymatic study of the mode of action of pyrithiamine (neopyrithiamine).
  • D. Woolley
  • Medicine
  • The Journal of biological chemistry
  • 1951
TLDR
Experimental evidence is presented to show that pyrithiamine (neopyrithienine) inhibits the synthesis of cocarboxylase by the enzyme system found in chicken blood. Expand
The antithiamine effect of the 2-n-butylpyrimidine homologue of thiamine.
TLDR
The antithiamine activity of the 2- n-butylpyrimidine homologue of thiamine (2-n- butyl-5(4-methyl-5-@hydroxyethyl-thiazolium bromide)-methyl-G-aminopyrimidine hydrobromide) is reported. Expand
A Pyrimidine Analog of Thiamine and the Growth of Fungi.
  • W. Robbins
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1942
This compound was synthesized by Miss Yolanda A. Tota. It is stated to be at least as stable to heat as thiamine. I have tested this compound with three fungi, Phycomyces Blakesleeanus, PythiomorphaExpand
The antithiamine activity of the 2-alkylthio analogs of thiamine in microorganisms.
  • T. Sakuragi
  • Biology, Medicine
  • Archives of biochemistry and biophysics
  • 1958
TLDR
2-Methylthio, 2-ethylthios, and 2- n -propylthio analogs of thiamine were synthesized and their inhibitory effect for the growth of Kloeckera brevis and Saccharomyces carlsbergensis was compared with pyrithiamine and oxythiamine. Expand
The natural occurrence, enzymatic formation, and biochemical significance of a hydroxyethyl derivative of thiamine pyrophosphate.
Thiamine pyrophosphate is required as a coenzyme for several enzymatic reactions which result in the decarboxylation of cu-keto acids with the concomitant formation of corresponding aldehydes orExpand
Influence of Anti-Metabolites of Essential Vitamins on Growth and Acid Production of Lactobacillus acidophilus (Hadley).∗
  • S. Dreizen, E. Scholz, T. Spies
  • Biology, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1948
Conclusion The findings reveal that pantoyltaurine, pyridine-3-sulfonic acid and pyrithiamine will inhibit the growth and acid production of the Lactobacillus acidophilus (Hadley) when present inExpand
SELECTIVE REVERSIBLE INHIBITION OF MICROBIAL GROWTH WITH PYRITHIAMINE
TLDR
It was concluded that formation of thiamine or other antagonistic substance did not provide an adequate explanation of the resistance of these species to the action of pyrithiamine. Expand
Antibacterial Action of a Pyridine Analogue of Thiamine
  • O. Wyss
  • Medicine, Biology
  • Journal of bacteriology
  • 1943
hemolysed erythrocytes when the washings preceding hemolysis were free from the virus; although intact erythrocytes also proved infectious, the yield of the virus was lower than in hemolysedExpand
Effect of Oxythiamine on Infection of Mice with the Lansing Strain of Poliomyelitis Virus.∗
  • J. H. Jones, C. Foster, W. Henle
  • Biology, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1948
TLDR
A significant degree of protection was induced in all the groups on the oxythiamine as compared with those on the normal diet, although this protection was not quite as marked as in the mice on the low-thiamine diet. Expand
...
1
2
3
4
5
...