THIAMIN DEFICIENCY AND ALCOHOLISM

@article{Leevy1982THIAMINDA,
  title={THIAMIN DEFICIENCY AND ALCOHOLISM},
  author={Carroll Moton Leevy},
  journal={Annals of the New York Academy of Sciences},
  year={1982},
  volume={378}
}
  • C. M. Leevy
  • Published 1 March 1982
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
This report summarizes studies on the mechanism, significance, and therapeutic implications of thiamin deficiency in the alcoholic. A deficiency or malutilization of thiamin alters decarboxylation of pyruvate and alpha-ketoglutarate; decreases transketolase formation; and reduces conversion of tryptophan to nicotinic acid and nicotinamide. The resulting alteration in intermediary metabolism produces gastrointestinal, cardiac, and central nervous system changes. Thiamin-mediated effects on… 

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