THE ROLE OF THE THYMUS IN DEVELOPMENT OF IMMUNOLOGIC CAPACITY IN RABBITS AND MICE

@article{Good1962THERO,
  title={THE ROLE OF THE THYMUS IN DEVELOPMENT OF IMMUNOLOGIC CAPACITY IN RABBITS AND MICE},
  author={Robert A. Good and Agustin P. Dalmasso and Carlos Mart{\'i}nez and Olga K. Archer and James C. Pierce and Ben W. Papermaster},
  journal={The Journal of Experimental Medicine},
  year={1962},
  volume={116},
  pages={773 - 796}
}
In rabbits, complete thymectomy before the age of 5 days produced immunologic deficiency in the adult animals, as indicated by reduced antibody production to bovine serum albumin and bacteriophage T(2). Homotransplantation immunity was unaffected, however. In an inbred strain of mice, complete neonatal thymectomy resulted in complete inability of the 60-day-old animals to form antibody to bacteriophage T(2). Inbred mice, completely thymectomized at birth, had a deficient homograft response… CONTINUE READING

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