THE ROLE OF THE COMPLEMENT SYSTEM IN ISCHEMIA-REPERFUSION INJURY

@article{Arumugam2004THERO,
  title={THE ROLE OF THE COMPLEMENT SYSTEM IN ISCHEMIA-REPERFUSION INJURY},
  author={Thiruma V. Arumugam and Ian A. Shiels and Trent M. Woodruff and Dn. Granger and Stephen M. Taylor},
  journal={Shock},
  year={2004},
  volume={21},
  pages={401-409}
}
Ischemia-reperfusion (I/R) injury is a common clinical event with the potential to seriously affect, and sometimes kill, the patient. Interruption of blood supply causes ischemia, which rapidly damages metabolically active tissues. Paradoxically, restoration of blood flow to the ischemic tissues initiates a cascade of pathology that leads to additional cell or tissue injury. I/R is a potent inducer of complement activation that results in the production of a number of inflammatory mediators… 
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TLDR
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TLDR
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TLDR
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TLDR
This review gives an overview of the application of these anti-coagulants in several animal models of I/R injury in critical organs and describes the effects of these proteins on cellular processes including inflammation and apoptosis.
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TLDR
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TLDR
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TLDR
Investigation of the effect of C1 INH on complement deposition and endothelial cell activation in a rat model of hind limb I/R injury reveals a range of pathologic changes seen in patients with elective surgery on extremities requiring prolonged arterial occlusion.
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