Corpus ID: 87291517


  author={Y. Aksoy},
T Klin Tip Bilimleri 2002, 22 442 Hucresel ya amin sureklili i karma ik biyokimyasal tepkimelerin denge icinde yurumesine ba lidir. Bu dengeyi bozacak yonde ortaya cikan endojen ve/veya eksojen kaynakli faktorler hucre hasarina yol acarlar. Bunlar icinde oksidatif stres farkli patolojik durumlarin ortaya cikmasi nedeniyle gittikce onem kazanmakta ve ara tirmacilari bu yonde ara tirma yapmaya yoneltmektedir. Radikal reaksiyonlari hucre homeostazinin bir parcasidir. Sa likli hucreler homeostatik… Expand
Gama-glutamil transferazın oksidatif stres ve kardiyovasküler hastalıklarla ilişkisi
The primary role of the gamma-glutamyltransferase (GGT) is to break down the extracellular glutathione (GSH) in order to provide precursor amino acids especially cysteine, required for the intracellular GSH synthesis, which shows an antioxidant effect. Expand
Gama-glutamil transferazin oksidatif stres ve kardiyovasküler hastaliklarla ilişkisi Association of gamma-glutamyltransferase with oxidative stress and cardiovascular diseases
Recent knowledge on the association between GGT and oxidative stress as well as the importance of GGT activity in the pathogenesis and clinical evaluation of Cardiovascular Diseases has been discussed. Expand
Effects of a-lipoic acid on DNA damage, protein oxidation, lipid peroxidation, and some biochemical parameters in sub-chronic thinner-addicted rats
The present study was carried out to determine the effects of sub-chronic thinner addiction on the oxidant-antioxidant balance, the relation between toxicity and oxidative stress, and a possibleExpand
Resveratrol Attenuates Benzo(a)pyrene-Induced Dysfunctions, Oxidative Stress and Apoptosis in Pancreatic Beta-Cells
The data showed that resveratrol could reverse the oxidative alterations, functional impairments and the carcinogenetic effects of benzo(a)pyrene in pancreas beta-cells. Expand
Evaluation of oxidant–antioxidant status in oral toxicity of fish oil methyl esters and diesel fuel in male rats
  • L. Aksoy
  • Chemistry, Medicine
  • Toxicology and industrial health
  • 2015
It was observed that fish oil biodiesel does not induce as much oxidative damage as does the diesel fuel and it is suggested that fishOil biodiesel should be preferred as an alternative to the diesel. Expand
Aksoy rats antioxidant status in oral toxicity of fish oil methyl esters and diesel fuel in male − Evaluation of oxidant
This study was conducted to compare the effects of oral toxicity induced by fish oil biodiesel and diesel fuel. Diesel and fish oil biodiesel were administered by oral gavage to rats. For thisExpand
The time-dependent effect of exogenous epidermal growth factor administration on oxidant events in submandibular glands of New Zeland-type male rabbits
It was observed that processes including submandibular gland oxidative events and antioxidant responses during wound healing were affected by EGF. Expand


The human glutathione transferase P1-1 specific inhibitor TER 117 designed for overcoming cytostatic-drug resistance is also a strong inhibitor of glyoxalase I.
The inhibitory effects of TER 117 on GST P1-1 and glyoxalase I activities may act in synergy in the cell and improve the effectiveness of chemotherapy. Expand
Glutathione elevation and its protective role in acrolein-induced protein damage in synaptosomal membranes: relevance to brain lipid peroxidation in neurodegenerative disease
Protection by increased in-vivo GSH levels against acrolein-induced oxidative stress at levels found in AD brain is demonstrated and is consistent with the notion that methods to increase endogenous glutathione levels in neurodegenerative diseases associated with oxidative stress may be promising. Expand
Possible mechanisms responsible for the increased ascorbic acid content of Plasmodium vinckei-infected mouse erythrocytes.
Observations suggest that the increased uptake of dehydroascorbic acid into parasitized red blood cells may be a result of enhanced dehydration-reducing capacity, whilst the presence of the parasite induces a selective increase in the permeability of the erythrocyte plasma membrane to ascorbic acid. Expand
Role of oxidative stress and antioxidant therapy in alcoholic and nonalcoholic liver diseases.
  • C. Lieber
  • Chemistry, Medicine
  • Advances in pharmacology
  • 1997
PPC provided total protection against alcohol-induced septal fibrosis and cirrhosis in the baboon and it abolished an associated twofold rise in hepatic F2-isoprostanes, a product of lipid peroxidation. Expand
Role of vitamin E in glutathione-induced oxidant stress: methemoglobin, lipid peroxidation, and hemolysis.
Comparisons between normal RBC and vitamin E-deficient RBC suggest that vitamin E has little effect on the inward diffusion of extra-cellular H(2)O(2). Expand
Riboflavin deficiency in man: effects on haemoglobin and reduced glutathione in erythrocytes of different ages.
Glutathione reductase and aspartate aminotransferase activities and concentrations of reduced glutathione and oxyhaemoglobin all declined with age, while methaemogloblin, sulphaemoglobin and susceptibility to peroxide increased with age. Expand
Age-correlated modifications of copper-zinc superoxide dismutase and glutathione-related enzyme activities in human erythrocytes.
It is found that there is a negative correlation between age and activities of CuZn-SOD, GSSG-RD, and GSH-S-T activities, but no sex-related differences in erythrocyte CuZN-S OD, G SSG- RD, G SH-Px, and H2O2 activities are found. Expand
Inhibitors of Mitochondrial Respiration, Iron (II), and Hydroxyl Radical Evoke Release and Extracellular Hydrolysis of Glutathione in Rat Striatum and Substantia Nigra
The results of the present investigation suggest that the release and γ‐GT/dipeptidase‐mediated hydrolysis of GSH to glutamate, glycine, and CySH may be important factors involved with the degeneration of dopamine neurons. Expand
N-acetyl-L-cysteine for preventing lung reperfusion injury after liver ischemia-reperfusion: a possible dual protective mechanism in a dose-response study.
Lung treatment with NAC during its reperfusion with IR liver effluent prevented ALI, and GSH replenishment accounted for lung protection, but its content did not correlate directly with grade of protection; NAC itself seemingly afforded lung protection as well. Expand
Inhibition of glutathione S‐transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance
The ubiquitous expression of GSTs in different malignancies suggests that the addition of nontoxic reversing agents such as antimalarials could enhance the efficacy of a variety of alkylating agents. Expand