• Corpus ID: 87291517


  author={Yasemin Erkal Aksoy},
T Klin Tip Bilimleri 2002, 22 442 Hucresel ya amin sureklili i karma ik biyokimyasal tepkimelerin denge icinde yurumesine ba lidir. Bu dengeyi bozacak yonde ortaya cikan endojen ve/veya eksojen kaynakli faktorler hucre hasarina yol acarlar. Bunlar icinde oksidatif stres farkli patolojik durumlarin ortaya cikmasi nedeniyle gittikce onem kazanmakta ve ara tirmacilari bu yonde ara tirma yapmaya yoneltmektedir. Radikal reaksiyonlari hucre homeostazinin bir parcasidir. Sa likli hucreler homeostatik… 

Gama-glutamil transferazın oksidatif stres ve kardiyovasküler hastalıklarla ilişkisi

The primary role of the gamma-glutamyltransferase (GGT) is to break down the extracellular glutathione (GSH) in order to provide precursor amino acids especially cysteine, required for the intracellular GSH synthesis, which shows an antioxidant effect.

Gama-glutamil transferazin oksidatif stres ve kardiyovasküler hastaliklarla ilişkisi Association of gamma-glutamyltransferase with oxidative stress and cardiovascular diseases

Recent knowledge on the association between GGT and oxidative stress as well as the importance of GGT activity in the pathogenesis and clinical evaluation of Cardiovascular Diseases has been discussed.

Effects of a-lipoic acid on DNA damage, protein oxidation, lipid peroxidation, and some biochemical parameters in sub-chronic thinner-addicted rats

The results indicated that a-lipoic acid has a protective and balancing effect against complications derived from thinner inhalation in rats.

Resveratrol Attenuates Benzo(a)pyrene-Induced Dysfunctions, Oxidative Stress and Apoptosis in Pancreatic Beta-Cells

The data showed that resveratrol could reverse the oxidative alterations, functional impairments and the carcinogenetic effects of benzo(a)pyrene in pancreas beta-cells.

Evaluation of oxidant–antioxidant status in oral toxicity of fish oil methyl esters and diesel fuel in male rats

  • L. Aksoy
  • Biology, Environmental Science
    Toxicology and industrial health
  • 2015
It was observed that fish oil biodiesel does not induce as much oxidative damage as does the diesel fuel and it is suggested that fishOil biodiesel should be preferred as an alternative to the diesel.

Aksoy rats antioxidant status in oral toxicity of fish oil methyl esters and diesel fuel in male − Evaluation of oxidant

  • L. Aksoy
  • Biology, Environmental Science
  • 2013
It was observed that fish oil biodiesel does not induce as much oxidative damage as does the diesel fuel, and it is suggested that fishOil biodiesel should be preferred as an alternative to the diesel.

The time-dependent effect of exogenous epidermal growth factor administration on oxidant events in submandibular glands of New Zeland-type male rabbits

It was observed that processes including submandibular gland oxidative events and antioxidant responses during wound healing were affected by EGF.

Protective Effect of Silymarin and Gallic Acid against Cisplatin-Induced Nephrotoxicity and Hepatotoxicity

Gallic acid silymarin had a protective effect on cisplatin-induced nephrotoxic and hepatotoxic effects, and gallic acid showed a significant increase in CAT and SOD activity in kidney tissue compared with the cisPlatin-treated group.



The human glutathione transferase P1-1 specific inhibitor TER 117 designed for overcoming cytostatic-drug resistance is also a strong inhibitor of glyoxalase I.

The inhibitory effects of TER 117 on GST P1-1 and glyoxalase I activities may act in synergy in the cell and improve the effectiveness of chemotherapy.

Riboflavin deficiency in man: effects on haemoglobin and reduced glutathione in erythrocytes of different ages

The role of riboflavin in those sytems controlling RBC integrity is discussed and the only significant differences noted in the RBC from marginally-rib oflavin-deficient subjects by comparison with controls, were lower glutathione reductase activities and higher concentrations of methaemoglobin.

Role of vitamin E in glutathione-induced oxidant stress: methemoglobin, lipid peroxidation, and hemolysis.

Comparisons between normal RBC and vitamin E-deficient RBC suggest that vitamin E has little effect on the inward diffusion of extra-cellular H(2)O(2).

Age-correlated modifications of copper-zinc superoxide dismutase and glutathione-related enzyme activities in human erythrocytes.

It is found that there is a negative correlation between age and activities of CuZn-SOD, GSSG-RD, and GSH-S-T activities, but no sex-related differences in erythrocyte CuZN-S OD, G SSG- RD, G SH-Px, and H2O2 activities are found.

Inhibitors of Mitochondrial Respiration, Iron (II), and Hydroxyl Radical Evoke Release and Extracellular Hydrolysis of Glutathione in Rat Striatum and Substantia Nigra

The results of the present investigation suggest that the release and γ‐GT/dipeptidase‐mediated hydrolysis of GSH to glutamate, glycine, and CySH may be important factors involved with the degeneration of dopamine neurons.

N-acetyl-L-cysteine for preventing lung reperfusion injury after liver ischemia-reperfusion: a possible dual protective mechanism in a dose-response study.

Lung treatment with NAC during its reperfusion with IR liver effluent prevented ALI, and GSH replenishment accounted for lung protection, but its content did not correlate directly with grade of protection; NAC itself seemingly afforded lung protection as well.

Inhibition of glutathione S‐transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance

The ubiquitous expression of GSTs in different malignancies suggests that the addition of nontoxic reversing agents such as antimalarials could enhance the efficacy of a variety of alkylating agents.

Alteration of erythrocyte glutathione, cysteine and glutathione synthetase in alcoholic and non-alcoholic cirrhosis.

Cirrhotic patients displayed a significant decrease of plasma GSH, as well as of plasma cysteine, that was related to the degree of liver disease but not to the nutritional conditions, while erythrocyte cysteines increased significantly in all cirrhotics, regardless of the severity of disease.