THE ROLE OF FREE OXYGEN RADICALS IN THE ACTIVATION OF THE NK CYTOLYTIC PATHWAY

@inproceedings{Helfand1982THERO,
  title={THE ROLE OF FREE OXYGEN RADICALS IN THE ACTIVATION OF THE NK CYTOLYTIC PATHWAY},
  author={Stephen L. Helfand and Jerome Werkmeister and John C. Roder},
  year={1982}
}
Publisher Summary This chapter discusses the role of free oxygen radicals in the activation of the natural killer (NK) cytolytic pathway. The cytolytic pathway can be divided into four discrete stages, which include recognition and binding to the target and triggering and activation of the lytic mechanisms. An examination of low-NK responsiveness in humans has shown that individuals with this stable, selective defect have normal frequencies of HNK-1+ NK cells, which bind normally to the tumor… CONTINUE READING