Corpus ID: 46604972

THE ROLE OF CYP 3 A 4 / 5 IN ALPRAZOLAM METABOLISM

@inproceedings{Allqvist2010THERO,
  title={THE ROLE OF CYP 3 A 4 / 5 IN ALPRAZOLAM METABOLISM},
  author={Annika Allqvist},
  year={2010}
}
Cytochrome P450 3A (CYP3A) enzyme family is involved in the metabolism of about 50 % of all drugs in clinical use. Among CYP3A, CYP3A4 and CYP3A5 are the major enzymes in adults; CYP3A5 is polymorphic and primarily expressed in black populations. CYP3A5 may therefore contribute significantly to the metabolism of CYP3A substrates in African populations. The impact of CYP3A5 expression on drug metabolism by CYP3A is fairly unknown. Therefore, a tool for assessment of both CYP3A4 and CYP3A5 using… Expand

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