THE PURPURAS

@article{Lotti1994THEP,
  title={THE PURPURAS},
  author={Torello M Lotti and Ilaria Ghersetich and Emiliano Panconesi},
  journal={International Journal of Dermatology},
  year={1994},
  volume={33}
}
Purpura is a discoloration of the skin due to extravasation of red blood cells. Pressure by fitigers or diascopy fails to blanch the lesion, thus distinguishing it from erythema and from telangiectasia, Purpuric lesions may have different aspects and sizes: Petechiae are small lesions up to 2 mm in diameter that often occur in crops; ecchymoses are larger, sometimes figurate lesions ("vibices" if litiear, "seals" if roughly annular), caused by extravasation of red blood cells,' The color of the… 

References

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TLDR
Close similarity is apparent between the members of that group of idiopathic pigmented purpuric eruptions which includes Schamberg's progressive pigmentary disorder, angioma serpiginosum of Hutchinson, Majocchi's purpura annularis telangiectodes and pigmented Purpuric lichenoid dermatitis.
Autoerythrocyte sensitization; a form of purpura producing painful bruising following autosensitization to red blood cells in certain women.
TLDR
Four patients with purpura who manifested an unusual response to bruising were studied, and special studies utilizing skin testing procedures indicated an abnormal tissue response of sensitivity to red blood cells.
Immunopathological investigations in purpura pigmentosa chronica.
TLDR
In vivo expression of several effector and/or accessory cell markers on lesional keratinocytes and infiltrate cells in purpura pigmentosa chronica is demonstrated for the first time.
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TLDR
The complement profiles suggest that more than one mechanism of vascular damage may be operative in a syndrome consisting of recurrent episodes of urticaria, arthralgia, abdominal pain, and (rarely) glomerulonephritis.
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Two distinct cellular patterns of necrotizing angiitis involving venules in skin of patients with clinically identical cutaneous lesions were appreciated by the 1 -mum-thick section technique. In
Pedigree demonstrating a sex-linked recessive condition characterized by draining ears, eczematoid dermatitis and bloody diarrhea.
TLDR
Genetic analysis of the family of an individual suffering from what appeared to be secondary thrombocytopenic purpura indictated that 16 of 40 male infants died, agreeing with the assumption that a sex-linked recessive gene is responsible for the primary deviation which leads to the death of these infants.
Possible Pathogenetic Mechanisms in Allergic Cutaneous Vasculitis
TLDR
A llergic cutaneous vasculitis is characterized by inflammation of small vessels and especially postcapillary venules, and may relapse or even have a chronic course.
Fanconi's anemia. Tumor-like warts, hyperpigmentation associated with deranged keratinocytes, and depressed cell-mediated immunity.
TLDR
It is speculated that the chromosomal aberrations, the depressed cell-mediated immunity, and the increased frequency of malignant neoplasms known to occur in patients with FA also reflect changes related to an increased susceptibility to viral infections.
Clinical and histopathologic spectrum of necrotizing vasculitis. Report of findings in 101 cases.
TLDR
Two histologic features were particularly notable in view of the clinical findings: vasculitis extending deep into the reticular dermis or subcutaneous tissue seemed to be associated more often with systemic disease such as malignancy or connective tissue disease, and the inflammatory infiltrate in patients with hypocomplementemia was composed almost exclusively of neutrophils.
Purpura caused by food and drug additives.
TLDR
Seven patients with allergic vascular purpura displayed hypersensitivity reactions after ingestion of azo dyes and benzoic acid compounds and improved on a diet free from the additives.
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