THE PRODUCTION OF THYROIDITIS AND ANTIBODY FOLLOWING INJECTION OF UNALTERED THYROGLOBULIN WITHOUT ADJUVANT INTO RABBITS PREVIOUSLY STIMULATED WITH ALTERED THYROGLOBULIN

@article{Weigle1965THEPO,
  title={THE PRODUCTION OF THYROIDITIS AND ANTIBODY FOLLOWING INJECTION OF UNALTERED THYROGLOBULIN WITHOUT ADJUVANT INTO RABBITS PREVIOUSLY STIMULATED WITH ALTERED THYROGLOBULIN},
  author={William O. Weigle},
  journal={The Journal of Experimental Medicine},
  year={1965},
  volume={122},
  pages={1049 - 1062}
}
  • W. Weigle
  • Published 30 November 1965
  • Medicine
  • The Journal of Experimental Medicine
Injection of rabbits with arsanil-sulfanil-thyroglobulin without adjuvant resulted in the production of hemagglutinating and precipitating antibody to native thyroglobulin and thyroiditis. Following a latent period of 1 month, these same rabbits responded to an injection of native thyroglobulin with an increase in both circulating antibody to native thyroglobulin and severity and frequency of thyroid lesions. Some rabbits initially immunized with arsanil-sulfanil-thyroglobulin also responded to… Expand
THE ROLE OF MYCOBACTERIA AND THE EFFECT OF PROTEOLYTIC DEGRADATION OF THYROGLOBULIN ON THE PRODUCTION OF AUTOIMMUNE THYROIDITIS
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References

SHOWING 1-10 OF 21 REFERENCES
THE INDUCTION OF AUTOIMMUNITY IN RABBITS FOLLOWING INJECTION OF HETEROLOGOUS OR ALTERED HOMOLOGOUS THYROGLOBULIN
  • W. Weigle
  • Chemistry, Medicine
  • The Journal of experimental medicine
  • 1965
TLDR
Experimental autoimmunity was produced in rabbits following injection of altered homologous thyroglobulin by coupling to chemically defined haptens and by heating, and with some preparations antibody to native thyrogLobulin as well as thyroid lesions were produced. Expand
IMMUNOLOGICAL UNRESPONSIVENESS TO PROTEIN ANTIGENS IN RABBITS. I. THE DURATION OF UNRESPONSIVENESS FOLLOWING A SINGLE INJECTION AT BIRTH.
TLDR
It is concluded that, in respect of the antigens used, their persistence in the extracellular body fluids is not a prerequisite for maintenance of immunological unresponsiveness. Expand
Sedimentation Characteristics of Human Thyroid Autoantibodies
Forty-six sera from patients with Hashimoto's thyroiditis were separated into 7S and 19S fractions by zone ultracentrifugation over sucrose density gradients. In each case at least 98 per cent of theExpand
THE IMMUNE RESPONSE OF BSA TOLERANT RABBITS TO INJECTIONS OF BSA FOLLOWING THE TERMINATION OF THE TOLERANT STATE.
TLDR
In rabbits which had their tolerant state terminated by injections of HSA, none of the antibody produced following a subsequent injection of BSA was specific either for BSA or H SA, but all was directed to the shared determinants. Expand
THE IMMUNE RESPONSE OF RABBITS TOLERANT TO BOVINE SERUM ALBUMIN TO THE INJECTION OF OTHER HETEROLOGOUS SERUM ALBUMINS
  • W. Weigle
  • Biology, Medicine
  • The Journal of experimental medicine
  • 1961
TLDR
It was concluded from results obtained with several heterologous albumins that immunological tolerance to BSA is directed to both the over-all antigenic or physical-chemical composition of the protein and the individual determinant groups present on the protein. Expand
TERMINATION OF ACQUIRED IMMUNOLOGICAL TOLERANCE TO PROTEIN ANTIGENS FOLLOWING IMMUNIZATION WITH ALTERED PROTEIN ANTIGENS
  • W. Weigle
  • Medicine
  • The Journal of experimental medicine
  • 1962
TLDR
Acquired tolerance to BSA in rabbits was terminated following the injection of certain preparations of altered BSA and results were discussed in relation to both the clonal selection theory of antibody production and autoimmunity. Expand
REACTION OF 7S AND 19S COMPONENTS OF IMMUNE RABBIT ANTISERA WITH HUMAN GROUP A AND AB RED CELLS.
TLDR
19S antibody is more avid and, on a molecular basis, is 750 times more efficient at agglutinating red cells than 7S antibody, and the valency and mode of attachment to the red cells of the antibodies. Expand
I131-Labelled antigen precipitation as a measure of quantity and quality of antibody.
TLDR
In experiments designed to determine the effect of external factors such as X radiation on the production of precipi­ tins, the natural animal to animal varia­ tion in the degree of the immune response requires that several antibody bleedings be done on each of a large number of animals if significant results are to be obtained. Expand
THE ADSORPTION OF PROTEINS ON ERYTHROCYTES TREATED WITH TANNIC ACID AND SUBSEQUENT HEMAGGLUTINATION BY ANTIPROTEIN SERA
  • S. Boyden
  • Chemistry, Medicine
  • The Journal of experimental medicine
  • 1951
TLDR
Treatment of sheep erythrocytes with suitable concentrations of tannic acid render them capable of adsorbing certain protein molecules from solution in saline, and small amounts of the antigens can be detected through their power to inhibit hemagglutination of the treated cells. Expand
A quantitative study of a technique of double diffusion in agar.
  • J. Preer
  • Biology, Medicine
  • Journal of immunology
  • 1956
TLDR
It was shown that band position is linearly related to the logarithm of the ratio of the antigen to antibody concentrations, which indicates the interaction between immunologically related proteins in double diffusion. Expand
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