• Corpus ID: 9537144

THE PINEAL GLAND : ITS PHYSIOLOGICAL AND PHARMACOLOGICAL

@inproceedings{SrinivasanTHEPG,
  title={THE PINEAL GLAND : ITS PHYSIOLOGICAL AND PHARMACOLOGICAL},
  author={R. Srinivasan}
}
Our perception of pineal gland function has attained new dimenaions during the last decade. The gland is active throughout the life of an individual and secretes melatonin, the major pineal hormone, and many indoles and polypeptides. The secretion of pineal gland is regulated not only by sympathetic nerve fibers but by other central pinealopetal projections also, Many neurotransmitter-receptor sites have been identified recently in the pineal gland. The gland plays an established role in… 

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References

SHOWING 1-10 OF 71 REFERENCES

Psychoactive drugs, pineal gland and affective disorders

  • V. Srinivasan
  • Psychology, Biology
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 1989

Neural pathways and neurotransmitters affecting melatonin synthesis.

The intact sympathetic innervation, the functional beta-adrenergic receptors, and the appropriate level of norepinephrine are all essential prerequisites for the circadian pattern of melatonin synthesis.

Pineal gland biorhythms: N-acetyltransferase in chickens and rats.

Circadian rhythms have been identified in chemical factors involved in the metabolism of serotonin in the pineal gland and regulation by environmental lighting in vertebrates with special emphasis on pineal N-acetyltransferase activity in rats and chickens.

Melatonin in humans.

  • M. KarásekK. Winczyk
  • Biology
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
  • 2006
The basic data on melatonin significance in human physiology and in pathological processes as well as its possible therapeutic significance are reviewed and discussed.

Changes in melatonin secretion with age and pubescence.

Levels of pineal gland melatonin were low during early infancy, increased to their highest values around 1 to 3 years and dropped progressively by 75 percent until young adulthood, when they remained fairly stable, the reverse of that of gonadotropin levels or gonadal activity in humans.

A role for melatonin as a timekeeping hormone in the ewe.

  • F. Karsch
  • Biology
    Journal of neural transmission. Supplementum
  • 1986
The systems which respond to the melatonin signal and convert it into changes in hypothalamic activity are highly complex and solid concepts are beginning to emerge and rich questions continue to arise, making this a fertile area for future research.

Effects of antidepressants and other psychotropic drugs on melatonin release and pineal gland function.

The significant effects on melatonin of other drugs which affect monoamine function and have psychotropic effects, including lithium, propranolol, amphetamine and several monoamine precursors, are in accord with previous suggestions that the study of pineal function and melatonin production provides a valuable model system for psychopharmacological investigations.

Synchronization of mammalian circadian rhythms by melatonin.

Rats whose circadian rhythms are disrupted or arrhythmic in constant light are synchronized by daily melatonin injection, and the rate and direction of responses to phase-shift of the zeitgeber can be altered with dailyMelatonin administration, suggesting melatonin may be useful therapeutically for such human desynchronizations as jet-lag and shiftwork.

Neuroendocrine changes characteristic of sexual maturation.

It is probable that stress and underweight act in blocking the pubertal development through the action of neurotransmitters, in particular catecholamines and beta-endorphins.
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