THE PHARMACOKINETICS OF GLYCYRRHIZIC ACID EVALUATED BY PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING†

@article{Ploeger2001THEPO,
  title={THE PHARMACOKINETICS OF GLYCYRRHIZIC ACID EVALUATED BY PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING†},
  author={B. Ploeger and T. Mensinga and A. Sips and W. Seinen and J. Meulenbelt and J. DeJongh},
  journal={Drug Metabolism Reviews},
  year={2001},
  volume={33},
  pages={125 - 147}
}
Glycyrrhizic acid is widely applied as a sweetener in food products and chewing tobacco. In addition, it is of clinical interest for possible treatment of chronic hepatitis C. In some highly exposed subjects, side effects such as hypertension and symptoms associated with electrolyte disturbances have been reported. To analyze the relationship between the pharmacokinetics of glycyrrhizic acid in its toxicity, the kinetics of glycyrrhizic acid and its biologically active metabolite glycyrrhetic… Expand
[Novel formulations of a liver protection drug glycyrrhizin].
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Laminaria japonica increases plasma exposure of glycyrrhetinic acid following oral administration of Liquorice extract in rats.
Glycyrrhizic acid and 18β-glycyrrhetinic acid recover glucocorticoid resistance via PI3K-induced AP1, CRE and NFAT activation.
  • T. Kao, Chi-Hao Wu, G. Yen
  • Biology, Medicine
  • Phytomedicine : international journal of phytotherapy and phytopharmacology
  • 2013
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3
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References

SHOWING 1-10 OF 89 REFERENCES
Physiologically based pharmacokinetic modeling of glycyrrhizic acid, a compound subject to presystemic metabolism and enterohepatic cycling.
Pharmacokinetic profile of glycyrrhizin in healthy volunteers by a new high-performance liquid chromatographic method.
Rapid estimation of glycyrrhizin and glycyrrhetinic acid in plasma by high-speed liquid chromatography.
Glycyrrhizic acid in liquorice--evaluation of health hazard.
  • F. C. Størmer, R. Reistad, J. Alexander
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1993
Pharmacokinetics of glycyrrhetic acid, a major metabolite of glycyrrhizin, in rats.
Kinetics and dynamics of orally administered 18 beta-glycyrrhetinic acid in humans.
The metabolism of carbenoxolone in the rat.
...
1
2
3
4
5
...