• Corpus ID: 14126146

THE PATHOPHYSIOLOGY OF ALZHEIMER'S DISEASE AND DIRECTIONS IN TREATMENT

@inproceedings{Morrison2005THEPO,
  title={THE PATHOPHYSIOLOGY OF ALZHEIMER'S DISEASE AND DIRECTIONS IN TREATMENT},
  author={Ann K. Morrison and Constantine G Lyketsos},
  year={2005}
}
The pathophysiology of Alzheimer’s disease (AD) is complex, involving several neurotransmitter systems and pathophysiologic processes. The 3 hallmarks of AD—β-amyloid plaques, neurofibrillar y tangles, and neuronal cell death—are well known and central factors in AD pathology. These hallmarks, combined with our information on neurotransmitter involvement, are specific to AD based on the timing, sequence, and location of these changes. This article reviews the pathophysiology and course of brain… 
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References

SHOWING 1-10 OF 113 REFERENCES
Emerging prospects for the disease-modifying treatment of Alzheimer's disease.
Cholesterol and apolipoprotein E in Alzheimer's disease
  • A. Reiss
  • Biology
    American journal of Alzheimer's disease and other dementias
  • 2005
TLDR
Cholesterol has been demonstrated to modulate processing of APP to Aβ, a proteolytically derived product of amyloid precursor protein (APP), and high levels of cholesterol are associated with increased risk of AD.
Inflammation and Alzheimer’s disease
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
TLDR
It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
Vitamin E in Neurodegenerative Disorders: Alzheimer's Disease
TLDR
The data suggest that vitamin E may be effective against in vivo oxidation of CSF lipoproteins and brain lipids, and offer new perspectives in the treatment of AD and other neurodegenerative disorders.
Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results.
TLDR
Atorvastatin treatment may be of some clinical benefit and could be established as an effective therapy for Alzheimer disease if the current findings are substantiated by a much larger multicenter trial.
Oxidative imbalance in alzheimer’s disease
TLDR
The evidence for oxidative stress in Alzheimer’s disease and its likely sources and consequence in relation to other pathological changes is presented and could provide some protective mechanism to reduce oxidative stress and ensure that neurons do not rapidly succumb to oxidative insults.
Impact of Alzheimer's disease and rivastigmine treatment on activities of daily living over the course of mild to moderately severe disease
Loss of serotonin 5-HT2A receptors in the postmortem temporal cortex correlates with rate of cognitive decline in Alzheimer’s disease
TLDR
The data suggest that loss of neocortical 5-HT2A receptors may predict for faster cognitive decline in AD, and point to serotomimetics as potentially useful adjuvants to cholinergic replacement therapies.
...
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