THE ORNITHINE CYCLE IN NEUROSPORA AND ITS GENETIC CONTROL

@article{Srb1944THEOC,
  title={THE ORNITHINE CYCLE IN NEUROSPORA AND ITS GENETIC CONTROL},
  author={A. Srb and N. Horowitz},
  journal={Journal of Biological Chemistry},
  year={1944},
  volume={154},
  pages={129-139}
}
It has been emphasized by Haldane (1) that for studies of intermediary metabolism "the new science of genetics furnishes a very powerful method." Such a method is founded upon the general premises that genes control many of the chemical reactions within an organism, and that gene mutations by blocking a reaction chain at various points may, in effect, resolve a metabolic process into some of its constituent stages. For instance, the genetics of such diseases as alcaptonuria and cystinuria have… Expand

Figures and Tables from this paper

Biochemical genetics of Neurospora.
TLDR
This chapter highlights the current status of Neurospors research and attempts to relate this to the general problem of gene action. Expand
Genetics of arginine biosynthesis in Neurospora crassa.
TLDR
A large number of arginine-requiring mutants of Neurospora was isolated, using a strain already partially impaired in an enzyme of the pathway, and several new loci were defined and mapped, suggesting a bifunctional gene, possibly controlling two steps in ornithine synthesis. Expand
The use of mutants in the study of metabolism
TLDR
It will be shown that methods contributed by the field of biochemical genetics lead to conclusions that are consistent with, and complementary to, those derived from isotope and enzyme studies. Expand
Genetic control of aspartate transcarbamylase by the pyr-3 locus of Neurospora crassa.
TLDR
Kinetic analyses and genetic analyses lead to the conclusion that the pyr-3 locus controls two functions: the transcarbamylation of aspartate and a biochemically related function involved in the synthesis of carbamyl phosphate. Expand
Genetics and biochemistry of morphogenesis in Neurospora.
  • N. Mishra
  • Biology, Medicine
  • Advances in genetics
  • 1977
Publisher Summary This chapter attempts to present an account of the different aspects of Neurospora morphogenesis as elucidated by the different laboratories and to present an overall picture thatExpand
Arginine synthesis in Neurospora crassa; Genetic studies.
  • D. Newmeyer
  • Biology, Medicine
  • Journal of general microbiology
  • 1957
TLDR
Nine mutants of Neurospora crassa which require arginine as a nutrient but cannot use citrulline were obtained from various sources and it was concluded that the high arg + frequency is due to selection, and that the mutants might be pseudoalleles. Expand
Genetic studies of mutants of Neurospora crassa lacking ornithine transcarbamylase
TLDR
Arginine has long been of interest to chemists, biochemists and biologists because of its close relation¬ ship to urea and there were indications that arginine biosynthesis was more complex than originally believed. Expand
Enzymes of Deamination, Decarboxylation, Transmethylation and Intermediary Metabolism
Plants are autotrophic with regard to the amino acids and manufacture them from inorganic sources of nitrogen. Obviously then, they must possess all the necessary enzymes bringing about the synthesisExpand
Genetics and molecular biology of Neurospora crassa.
  • N. Mishra
  • Biology, Medicine
  • Advances in genetics
  • 1991
TLDR
It is obvious that further investigation of all aspects of the molecular biology of Neurospora as discussed in the chapter can provide new insights into the intricacies of nature and the mechanisms responsible for the maintenance of extra genes. Expand
Arginine Synthesis in Neurospora crassa
Nine mutants of Neurospora crassa which require arginine as a nutrient but cannot use citrulline were obtained from various sources. These fall into two classes, according to location in linkageExpand
...
1
2
3
4
5
...

References

SHOWING 1-9 OF 9 REFERENCES
Perspectives in Biochemistry
  • C. Long
  • The Yale Journal of Biology and Medicine
  • 1938
PERSPECTIVES IN BIOCHEMISTRY: Thirty-one essays presented to Sir Frederick Gowland Hopkins by past and present members of his laboratory. Edited by Joseph Needham and David E. Green. CambridgeExpand
Annual Review of Biochemistry
IN his story of his visit to India, which has so arrested the attention of all of us, Prof. A. V. Hill has emphasized the need for biological research in particular in order to solve the many complexExpand
Arch. Biochem
  • Arch. Biochem
  • 1944
Arch. Biochem
  • Arch. Biochem
  • 1943
J. Biol. Chem
  • J. Biol. Chem
  • 1943
Biochem. J
  • Biochem. J
  • 1941
Proc. Nut. Acad. SC
  • Proc. Nut. Acad. SC
  • 1941
physiol. Chem
  • physiol. Chem
  • 1932
The Inborn Factors In Disease