THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

  title={THE NF-$\kappa$B AND I$\kappa$B PROTEINS: New Discoveries and Insights},
  author={Albert S. Baldwin},
  journal={Annual Review of Immunology},
  • A. Baldwin
  • Published 1996
  • Biology
  • Annual Review of Immunology
▪ Abstract The transcription factor NF-κB has attracted widespread attention among researchers in many fields based on the following: its unusual and rapid regulation, the wide range of genes that it controls, its central role in immunological processes, the complexity of its subunits, and its apparent involvement in several diseases. A primary level of control for NF-κB is through interactions with an inhibitor protein called IκB. Recent evidence confirms the existence of multiple forms of IκB… 

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