Corpus ID: 87173915

THE N-DEMETHYLATION OF BUTYNAMINE

@article{Mcmahon1962THENO,
  title={THE N-DEMETHYLATION OF BUTYNAMINE},
  author={R. Mcmahon and N. R. Easton},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={1962},
  volume={135},
  pages={128-133}
}
  • R. Mcmahon, N. R. Easton
  • Published 1962
  • Chemistry
  • Journal of Pharmacology and Experimental Therapeutics
  • Butynamine (3 - methyl - 3 - [N - t - butyl- methylamino]-butyne-1), a hypotensive amine, is N-demethylated by the microsomal enzymes of rat liver. The product of the demethylation reaction is des-N-methyl butynamine which in itself has hypotensive activity of short duration. The implication of the observation that butynamine, a highly hindered aliphatic amine, is a suitable substrate for the microsomal enzyme system is discussed. N-demethylation is the main in vivo metabolic pathway in the rat… CONTINUE READING
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