author={John J. Bittner},
  pages={462 - 463}
Females of the fostered C3H strain and the BAF1 hybrid generation, having a normal incidence of breast tumors of 1-2 per cent., were given, by mouth or injection, filtrates (Seitz filter) or extracts of glycerinated-treated tissue containing the active milk-influence for the development of spontaneous breast cancer. Sixty-three experimental mice were observed to have an incidence of 41 per cent. Thirty-six mice received unfiltered or untreated material and have had an incidence of 67 per cent… 
The milk agent in the origin of mammary tumors in mice.
The removal of the young from the uteri of females of cancerous strains was found to be more effective than foster nursing in preventing the development of mammary cancer in mice.
Partial Separation of the Mammary Tumor Milk Agent and a Comparison of Various Sources of the Agent
The present work was unde r t aken in an effort to s t udy more q u a n t i t a t i v e l y the cy top lasmic dist r ibu t ion of the agent by combin ing the technics of different ial cent r i fugat ion with those of serial di lut ion, and also, to a t t e m p t to find the most po ten t source of theAgent.
The mammary tumor virus (MTV).
  • P. Blair
  • Biology, Medicine
    Current topics in microbiology and immunology
  • 1968
During the early decades of this century, three factors were found to play major roles in the genesis of mammary tumors in mice: the genetic constitution of the mouse, hormonal stimulation, and the
Possible relationship of the estrogenic hormones, genetic susceptibility, and milk influence in the production of mammary cancer in mice.
The incidence of mammary tumors in the progeny of cancerous and noncancerous mothers of inbred strains suggests that there are at least 2 types of these neoplasms in mice.
Strain differences in response to diethylstilbestrol and the induction of mammary gland and bladder cancer in the rat.
The response of 3 inbred lines of rats to unphysiological stimulation from diethylstilbestrol are reported; the most conspicuous pathological lesions included pituitary adenomas fatty livers and bladder calculi and papillomas and pronounced strain differences were observed in the expression of these lesions.
Increased fluidity of serum lipids and development of spontaneous mammary tumors in C3H mice
The results have shown a marked increase in LFU in serum lipids associated with the development of spontaneous mammary tumors in C3H mice, and it is suggested that alterations in the dynamics of serum Lipids in the C2H system may have a direct relation to the induction and/or growth of spontaneous tumors in these mice.
Mus Tales: A Hands-On View
  • L. Young
  • Biology
    Journal of Mammary Gland Biology and Neoplasia
  • 2008
The mouse model for breast cancer has developed into a most effective means of dissecting and understanding this devastating disease, and the capability for the transplantation of tissues as well as gene manipulation make the transgenic mouse a major research resource.
Mammary gland neoplasia in long-term rodent studies.
Until there is enough information on the predictive value of mechanism-based toxicology for risk assessment, this approach should be used in conjunction with and validated by the traditional in vivo long-term bioassays, combined with comparative in vitro systems.
The neonatal Fc receptor is not required for mucosal infection by mouse mammary tumor virus
It is concluded that the neonatal Fc receptor (nFcR), expressed by enterocytes during the first two weeks of life, is downregulated at weaning, and its disappearance correlates with the onset of intestinal resistance to MMTV.