• Corpus ID: 46285779

THE MICROBIAL ECOSYSTEM OF THE DIGESTIVE TRACT

@inproceedings{2009THEME,
  title={THE MICROBIAL ECOSYSTEM OF THE DIGESTIVE TRACT},
  author={},
  year={2009}
}
  • Published 2009
  • Medicine
Colonisation resistance (CR) is the resistance encountered by ingested micro-organisms when they try to colonise the digestive tract. This review discusses various aspects of the CR, including factors involving the cooperation of host and indigenous microflora. Factors which affect the CR and may decrease it significantly include antibiotic treatment, severe illness, stress and possibly diet. Involvement of the immune system in the mucosa-associated intestinal microflora from birth is outlined… 

References

SHOWING 1-10 OF 33 REFERENCES
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The colonization resistance (CR) of the gastrointestinal tract to potential pathogens depends partly on factors within the host but to a greater extent on the normal (anaerobic) gut flora. Its
Colonization resistance of the digestive tract in conventional and antibiotic-treated mice.
TLDR
Germ-free mice contaminated with the intestinal flora of an antibiotic-treated animal and their offspring housed in a germ-free isolator showed high values of CR, and apparently, these anaerobes are responsible for CR in these and in conventional mice.
Biotyping of Enterobacteriaceae as a test for the evaluation of isolation systems.
TLDR
It is concluded that the isolation procedures were not completely effective and that the acute myeloid leukaemia and AML patients studied had a decreased colonization resistance of their digestive tract.
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TLDR
Experimental work in animals has indicated that colonization resistance (CR) decreases to extremely low values during decontamination as a result of the suppression of the anaerobic fraction of the intestinal flora, which renders the decontaminated individual extremely sensitive to colonization by microorganisms that are resistant to the antibiotics used forDecontamination.
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TLDR
New colonizing clostridia, enterobacteria and fungi were found both in the oropharynx and in the colon when erythromycin and clindamycin were administered and pronounced suppression of anaerobic bacteria was noticed when clind amycin was administered.
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β-Aspartylglycine can adequately be used as an indicator of colonisation-resistance as its presence reflects the absence of β-aspartylpeptide-degrading activity originating from a substantial number
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TLDR
These studies suggest that L. acidophilus in this type of preparation should be taken continuously in order to maintain high levels of lactobacilli in the intestine.
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TLDR
Gnotobiotic and SPF mice, therefore, provide experimental models for determining the nature of the mechanisms operating to confine indigenous bacteria to the gastrointestinal tract in normal, healthy animals.
Infection by and distribution of biotypes of Enterobacteriaceae species in leukaemic patients treated under ward conditions and in units for protective isolation in seven hospitals in Europe
TLDR
A linear correlation was found between the incidence of gram-negative infections and the number of cases in which these Enterobacteriaceae biotypes colonized the gastro-intestinal tract of patients and a leak in the isolation system was indicated.
Immunogenicity of Bacteroides isolated from mice: relationship between immunogenicity and cell wall antigens
TLDR
Three different strains of Bacteroides were isolated from feces and cecal contents of mice and the immunogenicity of the strains was determined by measuring the serum agglutinin titers after intraperitoneal antigen injection, suggesting that the surface antigens of the two strains are distinctly different.
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