THE MECHANISM OF PLACEBO ANALGESIA

@article{Levine1978THEMO,
  title={THE MECHANISM OF PLACEBO ANALGESIA},
  author={J. Levine and N. Gordon and H. Fields},
  journal={The Lancet},
  year={1978},
  volume={312},
  pages={654-657}
}
The effect of naloxone on dental postoperative pain was studied to examine the hypothesis that endorphins mediate placebo analgesia. All patients had extraction of impacted mandibular third molars with diazepam, N2O, and local block with mepivacaine. 3 h and 4 h after surgery naloxone or a placebo was given under randomised, double-blind conditions. Pain was evaluated on a visual analogue scale. Patients given naloxone reported significantly greater pain than those given placebo. Patients given… Expand
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