author={Mehmet Tugrul Cab{\'y}oglu and Neyhan Ergene and Uner Tan},
  journal={International Journal of Neuroscience},
  pages={115 - 125}
This study presents the result of the studies explaining the effects of acupuncture on various systems and symptoms. It has been determined that endomorphin-1, beta endorphin, encephalin, and serotonin levels increase in plasma and brain tissue through acupuncture application. It has been observed that the increases of endomorphin-1, beta endorphin, encephalin, serotonin, and dopamine cause analgesia, sedation, and recovery in motor functions. They also have immunomodulator effects on the… 
Mechanisms of Action for Acupuncture in the Oncology Setting
A biomedical database search for articles in the English-language literature revealed studies examining the effect of acupuncture on fibroblast cells, a decrease of inflammatory cytokines, an increase of T-lymphocytes, and increasing adenosine, neuropeptides, opioid peptides, peptide hormones, and stem cells.
Acupuncture mechanisms: Anesthesia, analgesia and protection on organ functions
The current evidence supports that acupuncture analgesia and its organ protection in anesthesia is associated with the integration of neuroendocrine-immune networks in the level of neurotransmitters, cytokines, hormones, neuronal ensembles, lymphocytes, and endocrine cells.
Acupuncture Treatment in Depression
The analysis examined data from 26 RCTs that investigated the effectiveness of manual, laser or electroacupuncture treatment, used as monotherapy or as augmentation therapy in patients with depression, and supported the use of acupuncture as a safe and promising therapy.
Evaluation of an acupuncture service in oncology
  • J. Salmon
  • Medicine
    Journal of Radiotherapy in Practice
  • 2011
It is demonstrated that acupuncture may benefit patients experiencing anxiety and/or fatigue associated with cancer, and a future randomised controlled trial focusing on the use of acupuncture for hot flushes associated with hormonal treatments for cancer would be worthwhile.
Due to its analgesic effect, in numerous „pain management clinics“, acupuncture represents a part of the protocole for remediation of pain syndromes such as: headache, trigeminal neuralgia, paresis n.
Acupuncture for Depression: A Review of Clinical Applications
While increasing numbers of patients are seeking acupuncture treatment for depression in recent years, there is limited evidence of the antidepressant (AD) effectiveness of acupuncture. Given the
Acupuncture for Symptom Management in a Menopausal Population: An Exploration of Mechanism and Experience
This early phase study examined the effects of a series of ten standard-protocol acupuncture treatments over four weeks in 12 healthy, but symptomatic, menopausal women and measured two biologic markers to evaluate effects of acupuncture on the autonomic nervous system as it relates specifically to the heart.
Acupuncture for Migraine: a Review of the Data and Clinical Insights
Results of acupuncture studies are quite variable and depend on multiple factors, including frequency, duration, and consistency of treatments, as well as acupoint selection, which will help guide the development of future studies.
Molecular mechanisms underlying the effects of acupuncture on neuropathic pain
Electroacupuncture and manual acupuncture could activate ephrin-B/EphB signaling in neuropathic pain rats and improve neurological function and the results showed that manual acupuncture and elec-puncture significantly reduced mechanical hypersensitivity following chronic constriction injury.
The effect of physiotherapy and acupuncture on psychocognitive, somatic, quality of life, and disability characteristics in TTH patients
A significant beneficial role of acupuncture, stretching, and physiotherapy on cognitive, psychosomatic pain measures, disability index, quality of life, and catastrophizing in patients with TTH was observed.


The effect of acupuncture on gastrointestinal function and disorders.
A review of studies from both the Chinese and Western literature supports the efficacy of acupuncture in the regulation of gastrointestinal motor activity and secretion through opioid and other neural pathways, but no firm conclusion can be drawn about the effectiveness in the treatment of specific gastrointestinal disorders because of the lack of properly randomized controlled trials.
The mechanisms of acupuncture analgesia : review and update
In conclusion, analgesia elicited by acupuncture occurs as a result of activation of the spinal cord, the PAG and the HPS inhibiting incoming nociception.
What is the material base of acupuncture? The nerves!
  • H. Fu
  • Biology, Chemistry
    Medical hypotheses
  • 2000
The lengthy discussion may conclude that nerve cells and the central nervous system are the real material base of acupuncture.
Acupuncture and the opioid system: implications in management of migraine.
Stimulation of auricular acupuncture points in weight loss.
[The peripheral afferent pathway in acupuncture analgesia].
Experiments demonstrated that vascular occlusion of the upper arm could not prevent the analgesic effect of acupuncture needling of a point on the hand from being mediated to other regions of the body as manifested by raising the thresholds of pain at those regions, and infiltration of procaine in the deep tissues around the point of acupuncture abolished entirely the analgesics effect.
The implication of central serotonin in electro-acupuncture tolerance in the rat.
Results obtained from different lines of analysis point to the conclusion that development of tolerance toprofoundly released 5-HT during prolonged EA stimulation may constitute one of themechanisms for EA tolerance.
Role of opioid peptides of rat's nucleus reticularis paragigantocellularis lateralis (RPGL) in acupuncture analgesia.
The results showed that electrical stimulation of theRPGL could increase the pain threshold and enhance the effect of AA, whereas lesion of the RPGL reduce the effectOf AA, and activation of the RPGs and the endogenous opioid peptides within it produce an advantageous effect on AA.
The implication of central serotonin in electro-acupuncture tolerance in the rat.
  • S. Li, J. Tang, J. Han
  • Biology
    Scientia Sinica. Series B, Chemical, biological, agricultural, medical & earth sciences
  • 1982
Results obtained from different lines of analysis point to the conclusion that development of tolerance to profoundly released 5-HT during prolonged EA stimulation may constitute one of the mechanisms for EA tolerance.