THE MALARIA/G.-6-P.D. HYPOTHESIS

@article{Luzzatto1979THEMH,
  title={THE MALARIA/G.-6-P.D. HYPOTHESIS},
  author={Lucio Luzzatto and Ulrich Bienzle},
  journal={The Lancet},
  year={1979},
  volume={313},
  pages={1183-1184}
}
A comparative study of peak total serum bilirubin level in glucose-6-phosphate dehydrogenase deficient and glucose-6-phosphate dehydrogenase normal neonates in neonatal hyperbilirubinemia
TLDR
The prevalence of severe NHB with G6PD deficiency among neonates in North East region is relatively high and babies with G 6PD deficiency have a higher chance of severe hyperbilirubinemia and developing complications like kernicterus and poor neurodevelopmental outcome.
A comparative study of peak total serum bilirubin level in neonates with ABO incompatibility , Rh incompatibility and G 6 PD deficiency .
TLDR
The prevalence of severe NHB with ABO incompatibility, Rh incompatibility and G6PD deficiency among neonates in North East region is high and babies with these factors have higher chances of severe hyperbilirubinemia and developing complications like kernicterus and poor neurodevelopmental outcome.
Association of Glucose-6-phosphate dehydrogenase deficiency and hyperbilirubinemia in neonates
TLDR
In G6PD deficient neonates’ hyperbilirubinemia is very severe type which may be a risk factor for neurological complications like kernicterus, so implementation of National control program for screening of G6 PD deficiency in neonates will reduce the complications and fatal conditions arising due to this inborn blood disorder.
Use of primaquine and glucose-6-phosphate dehydrogenase deficiency testing: Divergent policies and practices in malaria endemic countries
TLDR
There remains lack of consensus on the requirement for G6PD deficiency testing before prescribing primaquine radical cure regimens, and there is substantial room for improvement in radical cure policies and practices.
Etudes de cinétiques enzymatiques par polarisation dynamique nucléaire avec dissolution (D-DNP) : application à l'étape oxydative de la voie des pentoses phosphates (PPP)
L'une des voies principales du metabolisme cellulaire est la voie des Pentoses Phosphates (PPP). Cette voie metabolique est composee de deux cascades enzymatiques, une voie oxydative et une voie non
Immobilization Increases the Stability and Reusability of Pigeon Pea NADP+ Linked Glucose-6-Phosphate Dehydrogenase
TLDR
The present investigation is an attempt for immobilization of purified glucose-6-phosphate dehydrogenase from pigeon pea on different matrix and maximum immobilization was achieved when alginate was used as immobilization matrix.
Comparison of Spectrophotometry, Chromate Inhibition, and Cytofluorometry Versus Gene Sequencing for Detection of Heterozygously Glucose-6-Phosphate Dehydrogenase-Deficient Females
TLDR
Heterozygously G6PD-deficient females with a larger percentage of G6 PD-sufficient RBCs are missed by routine methods measuring total G 6PD activity, but the majority of these females can be detected with both chromate inhibition and cytofluorometry.
G6PD deficiency and fungal infections in patients with acute myeloid leukemia: less enzyme more fungus
TLDR
In deficient patients, the frequency of bronchial and wound infections was also increased compared with non-deficient patients, and the durations of systemic inflammatory response syndrome, sepsis, and days on antibiotics were three times longer in deficient than in non- deficient individuals.
Glucose-6-phosphate dehydrogenase deficiency and reduced haemoglobin levels in African children with severe malaria
TLDR
Moderate ( type A+) and severely (type A−) G6PD deficiency showed significant association with lower haemoglobin concentrations at baseline in African children with severe malaria without leading to severe malarial anaemia and there was no association of G6 PD variant types with parasite densities on admission.
Glucose-6-phosphate dehydrogenase (G6PD) deficiency among tribal populations of India - Country scenario
TLDR
Routine screening for G6PD deficiency should be undertaken in those tribal communities where its prevalence is high, since the tribal populations live in remote areas where malaria is/has been endemic, irrational use of antimalarial drugs could result in an increased number of cases.
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