A comparative study of peak total serum bilirubin level in glucose-6-phosphate dehydrogenase deficient and glucose-6-phosphate dehydrogenase normal neonates in neonatal hyperbilirubinemia
The prevalence of severe NHB with G6PD deficiency among neonates in North East region is relatively high and babies with G 6PD deficiency have a higher chance of severe hyperbilirubinemia and developing complications like kernicterus and poor neurodevelopmental outcome.
A comparative study of peak total serum bilirubin level in neonates with ABO incompatibility , Rh incompatibility and G 6 PD deficiency .
The prevalence of severe NHB with ABO incompatibility, Rh incompatibility and G6PD deficiency among neonates in North East region is high and babies with these factors have higher chances of severe hyperbilirubinemia and developing complications like kernicterus and poor neurodevelopmental outcome.
Association of Glucose-6-phosphate dehydrogenase deficiency and hyperbilirubinemia in neonates
In G6PD deficient neonates’ hyperbilirubinemia is very severe type which may be a risk factor for neurological complications like kernicterus, so implementation of National control program for screening of G6 PD deficiency in neonates will reduce the complications and fatal conditions arising due to this inborn blood disorder.
Use of primaquine and glucose-6-phosphate dehydrogenase deficiency testing: Divergent policies and practices in malaria endemic countries
- MedicinePLoS neglected tropical diseases
There remains lack of consensus on the requirement for G6PD deficiency testing before prescribing primaquine radical cure regimens, and there is substantial room for improvement in radical cure policies and practices.
Etudes de cinétiques enzymatiques par polarisation dynamique nucléaire avec dissolution (D-DNP) : application à l'étape oxydative de la voie des pentoses phosphates (PPP)
L'une des voies principales du metabolisme cellulaire est la voie des Pentoses Phosphates (PPP). Cette voie metabolique est composee de deux cascades enzymatiques, une voie oxydative et une voie non…
Immobilization Increases the Stability and Reusability of Pigeon Pea NADP+ Linked Glucose-6-Phosphate Dehydrogenase
- Biology, EngineeringThe Protein Journal
The present investigation is an attempt for immobilization of purified glucose-6-phosphate dehydrogenase from pigeon pea on different matrix and maximum immobilization was achieved when alginate was used as immobilization matrix.
Comparison of Spectrophotometry, Chromate Inhibition, and Cytofluorometry Versus Gene Sequencing for Detection of Heterozygously Glucose-6-Phosphate Dehydrogenase-Deficient Females
- BiologyThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Heterozygously G6PD-deficient females with a larger percentage of G6 PD-sufficient RBCs are missed by routine methods measuring total G 6PD activity, but the majority of these females can be detected with both chromate inhibition and cytofluorometry.
G6PD deficiency and fungal infections in patients with acute myeloid leukemia: less enzyme more fungus
- Medicine, BiologyLeukemia & lymphoma
In deficient patients, the frequency of bronchial and wound infections was also increased compared with non-deficient patients, and the durations of systemic inflammatory response syndrome, sepsis, and days on antibiotics were three times longer in deficient than in non- deficient individuals.
Glucose-6-phosphate dehydrogenase deficiency and reduced haemoglobin levels in African children with severe malaria
- Medicine, BiologyMalaria Journal
Moderate ( type A+) and severely (type A−) G6PD deficiency showed significant association with lower haemoglobin concentrations at baseline in African children with severe malaria without leading to severe malarial anaemia and there was no association of G6 PD variant types with parasite densities on admission.
Glucose-6-phosphate dehydrogenase (G6PD) deficiency among tribal populations of India - Country scenario
- Medicine, BiologyThe Indian journal of medical research
Routine screening for G6PD deficiency should be undertaken in those tribal communities where its prevalence is high, since the tribal populations live in remote areas where malaria is/has been endemic, irrational use of antimalarial drugs could result in an increased number of cases.
SHOWING 1-10 OF 10 REFERENCES
Suppression and stimulation of the in vitro immune response by chlorpromazine.
In this report, the results reported in this paper show that CPZ inhibits an early cellular interacting process in a lymphocyte response to concanavalin A mitogen rather than the subsequent process of DNA synthesis and cell proliferation.
Glucose-6-Phosphate Dehydrogenase Deficient Red Cells: Resistance to Infection by Malarial Parasites
- Biology, MedicineScience
The mechanism whereby the gene for glucose-6-phosphate dehydrogenase deficiency confers selective advantage against malaria to heterozygous females, and thus may have attained the polymorphic frequency occurring in populations living in areas with endemic malaria, is investigated.
Infection of reticulocytes by Plasmodium falciparum and Plasmodium malariae in hyperendemic indigenous malaria.
- MedicineAnnals of tropical medicine and parasitology
Genetic factors in malaria.
- BiologyBulletin of the World Health Organization
A model that relates genetic factors in Plasmodium and in man and that may account for certain features of host-parasite interactions is presented.
Glucose-6-phosphate dehydrogenase and malaria. Greater resistance of females heterozygous for enzyme deficiency and of males with non-deficient variant.
- Biology, MedicineLancet
Variability of red cell phenotypes between and within individuals in an unbiased sample of 77 heterozygotes for G6PD deficiency in Sardinia.
- BiologyAmerican journal of human genetics
It is suggested that somatic selection may be the main factor determining the phenotype variability of individual somatic cells in highly differentiated tissues of heterozygotes at the G6PD locozygotes for the GdMediterranean mutant.
Relationship between the Genes for Glucose-6-phosphate Dehydrogenase and for Haemoglobin in a Nigerian Population
- Biology, MedicineNature
Three common variants of glucose-6-phosphate dehydrogenase are encountered in this population, two of them with normal activity, A and B, and one associated with enzyme deficiency, A− (according to the nomenclature recommended by the World Health Organization).
Concurrent inhibition by chlorpromazine of concanavalin A-induced lymphocyte aggregation and mitogenesis
Con A binding to the lymphocyte surface membrane of T cells seems to be sufficient to induce blastogenesis, and con A has been reported to increase the fluidity of lymphocyte membranes after binding.
Inhibition of surface capping of macromolecules by local anaesthetics and tranquillisers
Capping can occur in the absence of cell locomotion, but if locomotion does occur the cap is found at the trailing end of the cell4, and some form of membrane activity then sweeps the clusters into the cap.
Antibodies to human caudate nucleus neurons in Huntington's chorea.
- Biology, MedicineThe Journal of clinical investigation
Data from this study may support an environmental or infectious factor somehow involved in the ultimate expression of Huntington's disease.