• Corpus ID: 33811055

THE IRIS REVIEW PROCESS : CHLOROPRENE AND THE CRITICALITY OF GOOD SCIENCE

@inproceedings{Mundt2017THEIR,
  title={THE IRIS REVIEW PROCESS : CHLOROPRENE AND THE CRITICALITY OF GOOD SCIENCE},
  author={Dr. Kenneth Mundt},
  year={2017}
}

References

SHOWING 1-10 OF 15 REFERENCES

A constrained maximum likelihood approach to evaluate the impact of dose metric on cancer risk assessment: application to β-chloroprene.

Epidemiologic Evidence for Chloroprene Carcinogenicity: Review of Study Quality and its Application to Risk Assessment

  • J. Bukowski
  • Medicine
    Risk analysis : an official publication of the Society for Risk Analysis
  • 2009
TLDR
The weight of evidence does not support any substantial link between chloroprene exposure and cancer, but inconsistencies and a lack of control for major confounders preclude drawing firmer conclusions.

Cancer incidence and mortality in a cohort of chloroprene workers from Armenia

TLDR
A dose–response relationship was suggested between liver cancer and indices of CP exposure, such as duration of employment, duration of high CP exposure and cumulative exposure to CP, which was below expectation.

Epidemiologic study of cancer mortality among chloroprene workers.

TLDR
Among the high-exposure occupations, maintenance mechanics seem to have the highest risk of cancers, and SMRs for liver, lung, and lymphatic cancers were significant in this group, suggesting that chloroprene exposure increases the risk of developing cancer.

Kinetic modeling of beta-chloroprene metabolism: II. The application of physiologically based modeling for cancer dose response analysis.

TLDR
The combined analysis of lung tumor response across species using the PBTK-derived internal dose provides an improved alternative to default pharmacokinetic interspecies adjustments for application to human health risk assessment.

Kinetic modeling of beta-chloroprene metabolism: I. In vitro rates in liver and lung tissue fractions from mice, rats, hamsters, and humans.

TLDR
Investigation of species-dependent in vitro kinetics of CD oxidation and subsequent 1-CEO metabolism by microsomal epoxide hydrolase and cytosolic glutathione S-transferases in liver and lung, tissues that are prone to tumor induction found differences in metabolism are relevant to understanding species differences in sensitivity to CD-induced liver and Lung tumorigenicity.

Cancer mortality among Moscow shoe workers exposed to chloroprene (Russia)

TLDR
The results for liver cancer point towards a carcinogenic effect of CP, and the association between CP exposure and risk of leukemia may be due to concomitant exposure to benzene.

Mortality of workers exposed to chloroprene.

  • S. Pell
  • Medicine
    Journal of occupational medicine. : official publication of the Industrial Medical Association
  • 1978
TLDR
The absence of excess lung cancer mortality in other high exposure occupational groups indicates that chloroprene exposure does not increase the risk of lung cancer.