THE IONIC MECHANISMS OF EXCITATORY AND INHIBITORY SYNAPTIC ACTION

@article{Eccles1966THEIM,
  title={THE IONIC MECHANISMS OF EXCITATORY AND INHIBITORY SYNAPTIC ACTION},
  author={John Carew Eccles},
  journal={Annals of the New York Academy of Sciences},
  year={1966},
  volume={137}
}
  • J. Eccles
  • Published 1 July 1966
  • Biology
  • Annals of the New York Academy of Sciences
There are two major classes of synapses that act by chemical transmission: the excitatory and inhibitory. Recently a third type of chemical synapse has been discovered-the presynaptic inhibitory synapse, but there is as yet no information on its ionic mechanism. Electron-microscopy is now revealing that the excitatory and inhibitory synapses are very similar in structure, though there is evidence of finer structural differences. In both, the presynaptic components have synaptic vesicles that… 

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The pharmacology of spinal postsynaptic inhibition.

Junctional Transmission I. Postsynaptic Mechanisms

The sections in this article are: Electrical Transmission Versus Chemical Transmision, Postsynaptic Responses at Excitatory Synapses, and Inhibitory Synapses.

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It is suggested that an evolutionary preserved role for excitatory GABA in immature cells provides an important mechanism in the formation of synapses and activity in neuronal networks.

Action of strychine on evoked potentials and postsynaptic responses of cat sensomotor cortical neurons

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SIZES OF END PLATE COMPARTMENTS, DENSITIES OF ACETYLCHOLINE RECEPTOR AND OTHER QUANTITATIVE ASPECTS OF NEUROMUSCULAR TRANSMISSION

  • M. SalpeterM. Eldefrawi
  • Biology, Medicine
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  • 1973
The area of the postsynaptic membrane and the volume of the synaptic cleft were calculated for the end plates of the diaphragm and sternomastoid of mouse and rat and it is concluded that the concentration of ACh receptor in the plane of thePostsynaptic membranes is considerably higher than that of A choline in the cleft during neuromuscular transmission.

The anionic permeability of the inhibitory postsynaptic membrane of hippocampal pyramidal cells

The present findings suggest that the anion permeability of the inhibitory postsynaptic membrane in hippocampal pyramidal cells is similar to that reported for spinal motoneurons.

Computer simulation study of the relationship between the profile of excitatory postsynaptic potential and stimulus-correlated motoneuron firing

The methods aimed at extracting information about long-lasting and complex postsynaptic potentials from stimulus-correlated MN firing, should be refined, and the theoretical considerations checked in computer simulations.

Filling in the gaps : cerebellar granule cell layer oscillations and the role of gap junctions in the anesthetized rat

The oscillatory power of signal in the presence of gap junction blockers carbenoxlone and mefloquine was examined, resulting in a consistent decrease in the power in oscillations between 5-15 Hz, adding to the mechanistic description of the genesis of cerebellar GCL oscillations.
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References

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A comparative approach to the problems of synaptic excitation and inhibition is adopted, which is especially concerned with those synaptic transmissions where there is antagonism between excitatory and inhibitory actions.

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The first aim of the present investigation was to employ a more extensive anion series in order to test the postulate that the differential permeability is explicable by the pore size, and it was found that the time course of the IPSP recovery varied according to the injected anion species.

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This lecture is to show that not only is there a special mechanism of chemical mediation interposed between the two cells, but that the neuromuscular junction possesses the specific synaptic properties which are essential for the integration of converging and conflicting signals in the authors' nerve centres.

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  • Biology
    Annals of the New York Academy of Sciences
  • 1959
The essence of a widely held view of neuromuscular transmission is that the arrival of a motor nerve action potential greatly enhances the release of acetylcholine from the motor axon terminals, and as a consequence, the end-plate membrane develops an increased ionic permeability resulting in a diminution of the potential difference ordinarily appearing across it.

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  • 1965
External micro-electrodes were used to stimulate non-myelinated motor nerve terminals and to record pre- and post-synaptic responses at the neuromuscular junction of the frog to determine the velocity of impulse propagation in motor nerve endings.

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Synaptic activities in the rostral segments (II, III and IV) of toad's spinal cord in situ were investigated by recording intracellular potentials of motoneurons by finding EPSP and IPSP were nearly equal in their time course.

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