THE INVOLVEMENT OF CYTOCHROME P 450 3 A 4 IN THE N-DEMETHYLATION OF L-a-ACETYLMETHADOL ( LAAM ) , NORLAAM , AND METHADONE

@inproceedings{Moody1997THEIO,
  title={THE INVOLVEMENT OF CYTOCHROME P 450 3 A 4 IN THE N-DEMETHYLATION OF L-a-ACETYLMETHADOL ( LAAM ) , NORLAAM , AND METHADONE},
  author={David E. Moody and Mario E. Alburges and Robert J. Parker and Jerry M. Collins and John M. Strong},
  year={1997}
}
The N-demethylation of LAAM, norLAAM, and methadone has been investigated in human liver microsomes and microsomes containing cDNA-expressed human P450s. Gas chromatography/ mass spectrometry methods allowed detection of norLAAM and dinorLAAM formation from LAAM, dinorLAAM formation from norLAAM, and EDDP and EMDP formation from methadone. The rates of N-demethylation varied 4to 7-fold in microsomes from four different donors with activities for LAAM and norLAAM consistently greater (5to 14… CONTINUE READING

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