THE INHIBITION OF STREPTOCOCCAL DESOXYRIBONUCLEASE BY RABBIT AND HUMAN ANTISERA

@article{Mccarty1949THEIO,
  title={THE INHIBITION OF STREPTOCOCCAL DESOXYRIBONUCLEASE BY RABBIT AND HUMAN ANTISERA},
  author={Maclyn Mccarty},
  journal={The Journal of Experimental Medicine},
  year={1949},
  volume={90},
  pages={543 - 553}
}
  • M. Mccarty
  • Published 30 November 1949
  • Biology, Medicine
  • The Journal of Experimental Medicine
Rabbit antisera against partially purified streptococcal desoxyribonuclease inhibit the action of the enzyme on its substrate. The activity of pancreatic desoxyribonuclease is not affected by these antisera. Similarly antibody against pancreatic nuclease does not inhibit the streptococcal enzyme. Certain patients develop inhibitory antibody to streptococcal desoxyribonuclease following streptococcal infections, occasionally in very high titer, although the proportion of patients showing an… 

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The author takes pleasure in acknowledging the able technical assistance of Miss Elizabeth Van Pelt
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