• Corpus ID: 86091269

THE INFLUENCE OF TWO RECOMBINANT SOLUBLEHLA MOLECULES ON NK CELL-MEDIATED LYSISOF CELLS WITH DIFFERENT HLA CLASS IEXPRESSION

@inproceedings{Sheykhi2003THEIO,
  title={THE INFLUENCE OF TWO RECOMBINANT SOLUBLEHLA MOLECULES ON NK CELL-MEDIATED LYSISOF CELLS WITH DIFFERENT HLA CLASS IEXPRESSION},
  author={A Sheykhi and Z Amir Ghofran},
  year={2003}
}
Background - The lytic function of natural killer (NK) cells is markedly influenced by recognition of class I major histocompatibility complex molecules (MHC). The soluble form of human MHC molecules (sHLA) has been reported to be secreted by lymphocytes and is presented in the normal human serum. The aim of this study was to evaluate the possible immunomodulatory effect of sHLA on NK cell lytic function. Methods - HLA class I expression on three different tumor cell lines including M4, K562… 
In vitro modulation of natural killer activity of human peripheral blood mononuclear cells against prostate tumor cell line
TLDR
It is demonstrated that varying the mitogen exposure to PBMCs affect the influence of iK562 on NK activity, and this effect appeared to be unrelated to the subsequent expression of NKG2D or IFN-γ secretion.

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