Corpus ID: 28324103

THE INFLUENCE OF SERTRALINE ON THE PHARMACOKINETICS OF CARVEDILOL . A PRECLINICAL STUDY ON RATS

@inproceedings{Abrudan2017THEIO,
  title={THE INFLUENCE OF SERTRALINE ON THE PHARMACOKINETICS OF CARVEDILOL . A PRECLINICAL STUDY ON RATS},
  author={Maria Bianca Abrudan and D. Muntean and M. Neag and L. Vlase and Ana-Maria Gheldiu},
  year={2017}
}
The objective of this study was to investigate the effect of multiple-dose sertraline on the pharmacokinetic profile of carvedilol in rats. Carvedilol was orally administrated in rats (3.57 mg/kg body mass (b.m.)) on the absence of sertraline or after a pre-treatment with multiple oral doses of sertraline (7.14 mg/kg b.m.). The plasma concentrations of carvedilol were estimated by HPLC-MS. After carvedilol co-administration with sertraline, an approximately 7.7-fold increase in the exposure of… CONTINUE READING

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