THE INDUCTION OF AUTOIMMUNITY IN RABBITS FOLLOWING INJECTION OF HETEROLOGOUS OR ALTERED HOMOLOGOUS THYROGLOBULIN

@article{Weigle1965THEIO,
  title={THE INDUCTION OF AUTOIMMUNITY IN RABBITS FOLLOWING INJECTION OF HETEROLOGOUS OR ALTERED HOMOLOGOUS THYROGLOBULIN},
  author={William O. Weigle},
  journal={The Journal of Experimental Medicine},
  year={1965},
  volume={121},
  pages={289 - 308}
}
  • W. Weigle
  • Published 31 January 1965
  • Chemistry, Medicine
  • The Journal of Experimental Medicine
Experimental autoimmunity was produced in rabbits following injection of altered homologous thyroglobulin. The thyroglobulin was altered by coupling to chemically defined haptens and by heating. With some preparations antibody to native thyroglobulin as well as thyroid lesions were produced. Injections of thyroglobulin coupled to the diazonium derivatives of arsanilic acid and sulfanilic acid were effective when given in either soluble form or incorporated into incomplete Freund's adjuvant… Expand
THE PRODUCTION OF THYROIDITIS AND ANTIBODY FOLLOWING INJECTION OF UNALTERED THYROGLOBULIN WITHOUT ADJUVANT INTO RABBITS PREVIOUSLY STIMULATED WITH ALTERED THYROGLOBULIN
  • W. Weigle
  • Medicine
  • The Journal of experimental medicine
  • 1965
TLDR
Injection of rabbits with arsanil-sulfanil-thyroglobulin without adjuvant resulted in the production of hemagglutinating and precipitating antibody to native thyroglOBulin and thyroiditis and some rabbits made a response to their own thyrogLobulin released from an autotransplant of thyroid tissue. Expand
Termination of aquired and natural immunological tolerance with specific complexes
It was possible to terminate the induced unresponsive state to bovine serum albumin (BSA) and the natural unresponsive state to autologous thyroglobulin in rabbits (RTg) by immunization withExpand
THE ANTIBODY RESPONSE IN RABBITS TO PREVIOUSLY TOLERATED ANTIGENS *
  • W. Weigle
  • Medicine
  • Annals of the New York Academy of Sciences
  • 1965
TLDR
The present report will be concerned with the termination of acquired immunological tolerance induced in neonatal rabbits and its similarity to thetermination of tolerance to self-constituents (autoimmunity). Expand
CELLULAR EVENTS DURING THE INDUCTION OF EXPERIMENTAL THYROIDITIS IN THE RABBIT
TLDR
The results support the suggestion that thyroiditis in the rabbit is mediated by antibody and there was an excellent correlation between the appearance of PFC in the thyroid gland and the appearances of thyroid lesions. Expand
TRANSFER OF EXPERIMENTAL AUTOIMMUNE THYROIDITIS BY SERUM FROM THYROIDECTOMIZED DONORS
TLDR
Successful transfer of thyroid lesions was seen when serum containing early antithyroglobulin antibody obtained from thyroidectomized donor animals at various times after immunization was injected into normal recipients in a sequential manner. Expand
The role of hapten-reactive T lymphocytes in the induction of autoimmunity in mice. I. Establishment of the experimental conditions for the termination of immunological tolerance to human gamma globulin.
TLDR
The role of hapten-reactive helper T cells in the termination of immunological tolerance is clearly shown and experimental supports to the hypothesis on the termination mechanism proposed by Weigle are provided. Expand
Spreading of antibody reactivity to non‐thyroid antigens during experimental immunization with human thyroglobulin
TLDR
It is concluded that at least part of the induced anti‐Tg antibodies may result from the expansion of B cell clones producing polyreactive natural autoantibodies, and polyreactivity of anti‐ Tg antibodies during the first stages of Tg‐immunization may be responsible for the intermolecular spreading of antibody response. Expand
The role of hapten-reactive T lymphocytes in the induction of autoimmunity in mice. II. Termination of self-tolerance to erythrocytes by immunization with hapten-isologous erythrocytes.
TLDR
These results, as a model for autoantibody production in mice, were discussed on the basis of cellular cooperation mediated by a hapten-mechanism, and are consistent with the hypothesis proposed by Weigle for the mechanism of termination of self-tolerance. Expand
Evidence for intramolecular B‐cell epitope spreading during experimental immunization with an immunogenic thyroglobulin peptide
Thyroglobulin (Tg) is a target autoantigen in autoimmune thyroid diseases, such as Graves’ disease (GD) and Hashimoto's thyroiditis. In a previous study we identified three 20mer Tg peptides bearingExpand
Cellular Basis of Immunological Unresponsiveness
TLDR
The present discussion will consider the experimental data concerning the cellular events and consequences of the interaction between antigen and antigen-reactive cells which lead to the state of specifically induced unresponsiveness. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 24 REFERENCES
TERMINATION OF ACQUIRED IMMUNOLOGICAL TOLERANCE TO PROTEIN ANTIGENS FOLLOWING IMMUNIZATION WITH ALTERED PROTEIN ANTIGENS
  • W. Weigle
  • Medicine
  • The Journal of experimental medicine
  • 1962
TLDR
Acquired tolerance to BSA in rabbits was terminated following the injection of certain preparations of altered BSA and results were discussed in relation to both the clonal selection theory of antibody production and autoimmunity. Expand
THE IMMUNE RESPONSE OF RABBITS TOLERANT TO BOVINE SERUM ALBUMIN TO THE INJECTION OF OTHER HETEROLOGOUS SERUM ALBUMINS
  • W. Weigle
  • Biology, Medicine
  • The Journal of experimental medicine
  • 1961
TLDR
It was concluded from results obtained with several heterologous albumins that immunological tolerance to BSA is directed to both the over-all antigenic or physical-chemical composition of the protein and the individual determinant groups present on the protein. Expand
Studies on organ specificity. V. Changes in the thyroid glands of rabbits following active immunization with rabbit thyroid extracts.
TLDR
The reduction in specific thyroid antigen content can be demonstrated best by complement fixation tests but it can be confirmed by precipitation tests using in both instances a rabbit antiserum containing a potent rabbit thyroid antibody as a reagent. Expand
Studies on organ specificity. II. Serological interrelationships among thyroid extracts of various species.
Summary 1.Antisera produced in rabbits by injection of crude extracts of thyroid glands gave crossreactions with thyroid extracts of various species in an irregular and unpredictable manner, thusExpand
THE IMMUNE RESPONSE OF BSA TOLERANT RABBITS TO INJECTIONS OF BSA FOLLOWING THE TERMINATION OF THE TOLERANT STATE.
TLDR
In rabbits which had their tolerant state terminated by injections of HSA, none of the antibody produced following a subsequent injection of BSA was specific either for BSA or H SA, but all was directed to the shared determinants. Expand
Studies on hypersensitivity. I. Delayed and Arthustype skin reactivity to protein conjugates in guinea pigs.
TLDR
Findings in the immunization of guinea pigs with proteins conjugated with picryl, acetyl and ethoxymethylene-phenyloxazolone groups are discussed in view of the light they may throw upon the relation of delayed hypersensitivity to antibody production and upon the process of immunization. Expand
THE CUTANEOUS REACTION TO SOLUBLE ANTIGEN-ANTIBODY COMPLEXES
TLDR
The finding of affected vessels in the complex and LPA reactions containing little or no antigen and antibody, while these components were present in adjacent areas, suggests that the antigen-antibody combination may cause vascular reaction and damage by the release of physiologically active mediators from the tissue or tissue fluid. Expand
Localization of Thyroid and Spinal Cord Autoantibodies by Fluorescent Antibody Technic∗
TLDR
Parts of normal spinal cords of rabbits treated with rabbit antisera produced by immunization of rabbits with rabbit spinal cord suspensions were stained with fluorescein conjugated goat antiserum to rabbit immune globulin, suggesting the myelin sheath as at least one of the antibody combining sites, though further histological studies are needed. Expand
THE PROPERTIES OF THYROGLOBULIN. X. THE EFFECT OF UREA.
TLDR
The properties of thyroglobulin in urea solutions can be understood if there is (a) a distribution of energy states amongst the protein molecules which governs the susceptibility to unfolding by urea, and (b) a large number of unfolded states in which each molecule of thyrolysis can exist. Expand
The properties of thyroglobulin. I. The effects of alkali.
  • H. Edelhoch
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1960
TLDR
With thyroglobulin extracted from calf thyroid tissue, a new component, which possessed quite similar sedimentation properties to that reported by Lundgren and Williams, was observed to form at higher ionic strengths when the pH was raised above the neutral range. Expand
...
1
2
3
...