author={Frank M. Berger and Milton Kletzkin and Bernard J. Ludwig and Solomon B. Margolin},
  journal={Annals of the New York Academy of Sciences},
Administration of meprobamate to suitable patients produces both tranquilization and muscular relaxation (Berger, 1956). Since elimination of one of these two actions not only could yield new and useful drugs, but might also shed some light on the interrelation between psychic and somatic tension, numerous compounds chemically related to meprobamate (Berger, 1954) were synthesized and subjected to pharmacological evaluation. Of these, N-isopropyl-2-methyl-Zpropyl-l , 3-propanediol dicarbamate… 

The pharmacology of propanediol carbamates.

Elucidation of the Mechanism of Action of Carisoprodol at GABAA Receptors

In whole-cell patch clamp studies, carisoprodol allosterically modulated and directly activated human α1β2γ2 GABAAR function in a barbiturate-like manner and produced picrotoxin-sensitive, inward currents that were significantly larger than those produced by meprobamate, suggesting carisOProdol may directly produce GABAergic effects in the absence of GABA.

Carisoprodol Intoxications and Serotonergic Features

Findings could indicate that an increased serotonin level in the central nervous system could explain some of the symptoms and signs of carisoprodol intoxications.

Impairment due to intake of carisoprodol.

The effect of scheduling and withdrawal of carisoprodol on prevalence of intoxications with the drug.

It is shown that the rescheduling and withdrawal of carisoprodol from the Norwegian market had a positive effect on the prevalence of car isoprodols in impaired driving, deaths and contacts regarding intoxications.

A Review - Carisoprodol as Skeletal Muscle Relaxant

In the world of pharmacology, the prescription of a medicine and its dosage play important role. Different physico-chemical methods are in vogue in describing the interactions of the drug molecule

The Chemistry of the Non-Steroidal Antipyretic Agents: Structure-Activity Relationships

For a long time human fever has been considered to be a result of an alteration in the body’s thermostat in the hypothalamus, in response to a variety of pyrogenic factors such as bacteria, viruses

Carisoprodol use and abuse in Norway: a pharmacoepidemiological study.

The extent of potential abuse of carisoprodol in Norway is explored and the skewedness in use indicated that it is a potential drug of abuse.

The role of pharmacoepidemiological studies in the market withdrawal of carisoprodol (Somadril®) in Europe.

The role pharmacoepidemiological studies on carisoprodol played in providing evidence for the risk of psychomotor impairment and traffic accidents, intoxications and abuse has been reviewed.

Drug-related information generates placebo and nocebo responses that modify the drug response.

OBJECTIVE Administration of the muscle relaxant carisoprodol and placebo was crossed with information that was agonistic or antagonistic to the effect of carisoprodol. It was investigated whether



The central depressant properties of o-toloxypropyl carbamates.

  • F. M. Berger
  • Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 1952
The paralyzing activity, toxicity and anticonvulsant action of mephenesin and certain o -toloxy propanols and their carbamate esters were determined and the anticonVulsant activity of the carbamate derivatives appears to be greater in intensity hut equally short in duration as that of the parent compounds.


A new method for the evaluation of analgesics has been described and pethidine hydrochloride has been found to possess one fifth to one sixth of the analgesic activity of morphine hydrochlorides against mild pain stimuli, but to be ineffective against severe pain.

The pharmacological properties of 2-methyl-2-n-propyl-1,3-propanediol dicarbamate (miltown), a new interneuronal blocking agent.

  • F. M. Berger
  • Biology
    The Journal of pharmacology and experimental therapeutics
  • 1954
A substance called Miltown, which has a marked and long lasting depressant effect on multineuronal reflexes but does not significantly affect monosynaptic reflexes, acts on the central nervous system and prevents the occurrence of the tonic extensor phase of maximal electroshock seizures.


Carisoprodol is a centrally acting skeletal muscle relaxant that differs from mephenesin and other relaxants in several respects and is particularly effective in releasing decerebrate rigidity but is only a weak strychnine antagonist.

A Method for Evaluating both Non-Narcotic and Narcotic Analgesics

  • E. SiegmundR. CadmusGi-en Lu
  • Medicine, Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1957
Summary A simple method has been designed for evaluating both non-narcotic and narcotic analgesics. The method is based upon the specific antagonism of analgesics to the typical “syndrome” produced

The influence of atropine and scopolamine on the central effects of DFP.

  • W. WescoeR. E. Green
  • Medicine, Biology
    The Journal of pharmacology and experimental therapeutics
  • 1948
Data indicate that atropine prevents or annuls the central actions of ACh, and the action of DFP could be prevented or abolished by the intravenous administration ofAtropine or scopolamine.

Effect of 2-methyl, 2-n-propyl-1,3-propanediol dicarbamate (Miltown) on Central Nervous System

Summary 2-methyl, 2-n-propyl, 1,3 propanediol dicarbamate has been shown to have a potent and persistent mephenesin-like action on multineuronal spinal and bulbar reflexes in the cat. Recordings of

Effects of scopolamine and atropine electroencephalographic and behavioral reactions due to hypothalamic stimulation.

  • V. Longo
  • Biology, Psychology
    The Journal of pharmacology and experimental therapeutics
  • 1956
Both alkaloids proved to be without action on the neurovegetative and behavioral response which follows hypothalamic stimulation and the relation of these results to the anticholinergic action exerted by the drugs at the level of the central nervous system is discussed.

Anticonvulsant Action of 2-Substituted-l,3-Propanediols

  • F. M. Berger
  • Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1949
2,2-Diethyl-l, 3-propanediol and certain other substituted 1,3-pro panediols possess qualitatively similar pharmacological properties as myanesin but differ in having a weaker paralysing action and a more powerful anticonvulsant action.

Effect of Pregnancy and Lactation on Granuloma Tissue Formation and Joint Permeability in Rats.∗

Pregnancy and lactation in the rat markedly influenced the formation of granuloma tissue induced by subcutaneously implanted cotton pellets and the protection of the synovialis against the injurious effects of formaldehyde is believed to be due primarily to an increase in the gluco-corticoid moiety of the unique complex of interacting steroids existing during pregnancy and to a lesser extent during lactation.