THE HISTORY, CHEMISTRY, AND PHARMACOLOGY OF CARISOPRODOL

@article{Berger1960THEHC,
  title={THE HISTORY, CHEMISTRY, AND PHARMACOLOGY OF CARISOPRODOL},
  author={Frank M. Berger and Milton Kletzkin and Bernard J. Ludwig and Solomon B. Margolin},
  journal={Annals of the New York Academy of Sciences},
  year={1960},
  volume={86}
}
Administration of meprobamate to suitable patients produces both tranquilization and muscular relaxation (Berger, 1956). Since elimination of one of these two actions not only could yield new and useful drugs, but might also shed some light on the interrelation between psychic and somatic tension, numerous compounds chemically related to meprobamate (Berger, 1954) were synthesized and subjected to pharmacological evaluation. Of these, N-isopropyl-2-methyl-Zpropyl-l , 3-propanediol dicarbamate… 

The pharmacology of propanediol carbamates.

Elucidation of the Mechanism of Action of Carisoprodol at GABAA Receptors

In whole-cell patch clamp studies, carisoprodol allosterically modulated and directly activated human α1β2γ2 GABAAR function in a barbiturate-like manner and produced picrotoxin-sensitive, inward currents that were significantly larger than those produced by meprobamate, suggesting carisOProdol may directly produce GABAergic effects in the absence of GABA.

Carisoprodol Intoxications and Serotonergic Features

Findings could indicate that an increased serotonin level in the central nervous system could explain some of the symptoms and signs of carisoprodol intoxications.

Impairment due to intake of carisoprodol.

The effect of scheduling and withdrawal of carisoprodol on prevalence of intoxications with the drug.

It is shown that the rescheduling and withdrawal of carisoprodol from the Norwegian market had a positive effect on the prevalence of car isoprodols in impaired driving, deaths and contacts regarding intoxications.

A Review - Carisoprodol as Skeletal Muscle Relaxant

In the world of pharmacology, the prescription of a medicine and its dosage play important role. Different physico-chemical methods are in vogue in describing the interactions of the drug molecule

The Chemistry of the Non-Steroidal Antipyretic Agents: Structure-Activity Relationships

For a long time human fever has been considered to be a result of an alteration in the body’s thermostat in the hypothalamus, in response to a variety of pyrogenic factors such as bacteria, viruses

Carisoprodol use and abuse in Norway: a pharmacoepidemiological study.

The extent of potential abuse of carisoprodol in Norway is explored and the skewedness in use indicated that it is a potential drug of abuse.

The role of pharmacoepidemiological studies in the market withdrawal of carisoprodol (Somadril®) in Europe.

The role pharmacoepidemiological studies on carisoprodol played in providing evidence for the risk of psychomotor impairment and traffic accidents, intoxications and abuse has been reviewed.

Drug-related information generates placebo and nocebo responses that modify the drug response.

OBJECTIVE Administration of the muscle relaxant carisoprodol and placebo was crossed with information that was agonistic or antagonistic to the effect of carisoprodol. It was investigated whether

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