Oligodendrocyte Kir4.1 Channels Clear Out Congested K+
- Epilepsy currents
The results indicate that Kir4.1 channels in oligodendrocytes play an important role in extracellular K+ homeostasis in white matter and that selective loss of this channel from oligod endodermictes is sufficient to impair K+ clearance and promote seizures. Expand
Astrocytic Atrophy Following Status Epilepticus Parallels Reduced Ca2+ Activity and Impaired Synaptic Plasticity in the Rat Hippocampus
- Medicine, Chemistry
- Front. Mol. Neurosci.
The magnitude of long-term-potentiation (LTP) was reduced after status epilepticus, but this suggests that the reduced Ca2+-dependent release of D-serine by astrocytes impairs initiation of synaptic plasticity, but does not explain the failure of LTP maintenance which may be responsible for cognitive decline associated with epilepsy. Expand