THE FIMBRIA-FORNIX/CINGULAR BUNDLE PATHWAYS: A REVIEW OF NEUROCHEMICAL AND BEHAVIOURAL APPROACHES USING LESIONS AND TRANSPLANTATION TECHNIQUES

@article{Cassel1997THEFB,
  title={THE FIMBRIA-FORNIX/CINGULAR BUNDLE PATHWAYS: A REVIEW OF NEUROCHEMICAL AND BEHAVIOURAL APPROACHES USING LESIONS AND TRANSPLANTATION TECHNIQUES},
  author={Jean C. Cassel and Elee Duconseille and H{\'e}l{\`e}ne Jeltsch and Bruno E. Will},
  journal={Progress in Neurobiology},
  year={1997},
  volume={51},
  pages={663-716}
}

Sympathetic sprouting: no evidence for muscarinic modulation of noradrenaline release in hippocampal slices of rats with fimbria-fornix lesions

TLDR
Lesion-induced sprouting of sympathetic fibers into the hippocampus is not accompanied by the emergence of a muscarinic modulation of NA release in this tissue, and that the sensitivity of the presynaptic stimulatory effect of nicotine was modified by the lesion.

Structural and functional recovery elicited by combined putrescine and aminoguanidine treatment after aspirative lesion of the fimbria–fornix and overlying cortex in the adult rat

TLDR
Promising results support the idea that coadministration of putrescine and aminoguanidine might become a potent way to foster structural and functional recovery in the adult mammalian CNS after injury.

Dissecting the Fornix in Basic Memory Processes and Neuropsychiatric Disease: A Review

TLDR
This review reveals that fornix damage causes cognitive deficits that closely mirror those resulting from hippocampal lesions, and emerging DWI findings link perturbations in this structure to schizophrenia, mood disorders, and eating disorders, although more research is needed.

Fimbria-fornix lesions compromise the induction of long-term potentiation at the Schaffer collateral-CA1 synapse in the rat in vivo.

TLDR
Results indicate that the FF lesion leads to an enduring defect in hippocampal long-term synaptic plasticity that may relate mechanistically to the cognitive deficits characterized in this model.

Using Fos Imaging in the Rat to Reveal the Anatomical Extent of the Disruptive Effects of Fornix Lesions

TLDR
The results show that fornix transection has widespread, but selective, effects on a network of structures normally activated by spatial memory processes, with these effects extending beyond the hippocampal formation.

Selective lesions of the entorhinal cortex, the hippocampus, or the fimbria-fornix in rats: a comparison of effects on spontaneous and amphetamine-induced locomotion

TLDR
It is shown that lesions of the fimbria-fornix, the hippocampus, and of the entorhinal cortex have different effects on spontaneous and amphetamine-induced hyperactivity, as they also have on learning and memory tasks.
...

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Cholinergic Deafferentation of Dorsal Hippocampus by Fimbria‐Fornix Lesioning Differentially Regulates Subtypes (m1‐m5) of Muscarinic Receptors

TLDR
By using antisera selective for each of the five molecularly defined subtypes (m1‐m5) of muscarinic receptors, significant changes were observed in the levels of expression for at least four receptor proteins.

Sympathetic Sprouting: Time Course of Changes of Noradrenergic, Cholinergic, and Serotonergic Markers in the Denervated Rat Hippocampus

TLDR
It is concluded that hippocampal noradrenaline concentration is a more sensitive marker for sympathetic sprouting than high‐affinity noradRenaline uptake and that functional in vitro studies on hippocampal sympathetic ingrowth appear to fit optimal conditions in the ventral hippocampus at a delay of at least 40 weeks after surgery.

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