THE EXCITATION AND DEPRESSION OF SPINAL NEURONES BY STRUCTURALLY RELATED AMINO ACIDS

@article{Curtis1960THEEA,
  title={THE EXCITATION AND DEPRESSION OF SPINAL NEURONES BY STRUCTURALLY RELATED AMINO ACIDS},
  author={David R. Curtis and Jeffrey Clifton Watkins},
  journal={Journal of Neurochemistry},
  year={1960},
  volume={6}
}
THE anions of aspartic and glutamic acids have potent excitatory action upon spinal neurones (CURTIS, PHILLIS and WATKINS, 1960); this is in marked contrast to the strongly depressant action exhibited by their respective a-decarboxylation products, 0-alanine and y-amino-n-butyric acid (GABA) (CURTIS, PHILLIS and WATKINS, 1959). The latter amino acids cause no significant change in the membrane resting potential of motoneurones, which is strong evidence that these substances are not inhibitory… Expand
EXCITATORY AMINO ACID RECEPTORS IN THE CENTRAL NERVOUS SYSTEM
Speculation on the possible role played by the physiologically occurring dicarboxylic amino acids L-aspartate and L-glutamate has continued from the time that Hayashi (1954) first described theExpand
The chemical excitation of spinal neurones by certain acidic amino acids
TLDR
The close similarity which has been observed between the action of cysteic acid and those of aspartic and glutamic acids has led to the inclusion of the sulphonic acid in this report. Expand
THE EXCITATION AND DEPRESSION OF MAMMALIAN CORTICAL NEURONES BY AMINO ACIDS.
Amino acids related to L-glutamic and gamma-amino-n-butyric acid have been administered electrophoretically, and by pressure ejection, into the extraneuronal environment of single neurones in theExpand
Excitatory Amino Acids: Membrane Physiology
The excitatory action of acidic amino acids on neuronal membranes was first revealed in electrophysiological studies on cortical neurons (Hayashi, 1954) and, subsequently, on spinal neurons (CurtisExpand
A pharmacological study of the depression of spinal neurones by glycine and related amino acids
TLDR
An analysis has been made in anaesthetised cats of the depression by glycine and related amino acids of the firing of spinal dorsal horn interneurones, Renshaw cells and cortical neurones, and the involvement of a glycine-like amino acid as a major spinal inhibitory transmitter is discussed. Expand
The hyperpolarization of spinal motoneurones by glycine and related amino acids
TLDR
The results indicate that glycine may be a major spinal inhibitory transmitter, in which case strychnine affects spinal postsynaptic inhibition by limiting the action of glycine upon subsynaptic inhibitory receptors. Expand
Excitation of mammalian central neurones by acidic amino acids.
TLDR
The depolarization of motoneurones by dl -homocysteate was not altered by changes in intracellular chloride concentration, or extracellular concentrations of tetrodotoxin sufficient to suppress spike generation, and the action of the amino acid thus probably resembles that of synaptically released excitatory transmitters. Expand
The Hyperpolarization of Spinal Motoneurones by Clycine and Related Amino Acids
Summary. Eleetrophoretically administered glycine, fl-alanine and GABA hyperpolarize spinal motoneurones in cats anaesthetized with pentobarbitone. The reversal potential for these hyperpolarizationsExpand
ELECTROPHYSIOLOGICAL ACTIONS OF KAINATE AND OTHER EXCITATORY AMINO ACIDS, AND THE STRUCTURE OF THEIR RECEPTORS
It is more than 20 years since Curtis and his colleagues demonstrated that the naturally occurring acidic amino acids L-glutamate and L-aspartate depolarize and excite neurones of the mammalianExpand
Acidic amino acids with strong excitatory actions on mammalian neurones
TLDR
There is evidence (Curtis, 1962) that the equilibrium potential for the conductance change, induced in the membrane of spinal motoneurones by L-glutamic acid, differs from that associated with excitatory transmitter action. Expand
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