THE EVOLUTIONARY DYNAMICS OF COMPLEX POLYMORPHISMS , ,

@article{Lewontin1960THEED,
  title={THE EVOLUTIONARY DYNAMICS OF COMPLEX POLYMORPHISMS , ,},
  author={Richard C. Lewontin and Ken‐ichi Kojima},
  journal={Evolution},
  year={1960},
  volume={14}
}
The theory of balanced polymorphism which has been elaborated by population geneticists, notably Sewall Wright and R. A. Fisher, has in the main been concerned with the effects of single loci. As theory generally goes apace with experiment, this accent on single locus polymorphisms has been due to the plethora of observational evidence relating to simple cases. It is sufficient to note the vast effort made by Dobzhansky and his co-workers in their elucidation of the inversion polymorphism of… 

Multilocus Systems in Evolution

Population studies of genetic variation and microevolution are classically discussed in terms of changes in gene frequencies and the maintenance of polymorphic loci that can be identified by

THE PROBABILITY OF FIXATION OF A MUTANT: THE TWO‐LOCUS CASE

  • W. Ewens
  • Biology
    Evolution; international journal of organic evolution
  • 1967
The quantitative investigation of problems in population genetics has mainly been concerned with the analysis of gene frequencies at a single locus, but recently interest has moved to multilocus behavior, and as a first step in this direction the two-locus case has received increasing attention.

Dynamics of chromosomal polymorphism and genetic load: an application of the two-locus multiplicative model with heterosis.

It is suggested that the genetic load exhibited by a particular gene arrangement depends on its frequency in the population and that rare gene arrangements will tend to carry more lethal genes than common ones.

Transient Linkage Disequilibrium in Drosophila

A transient linkage disequilibria is described between two allozyme loci in a laboratory population of Drosophila melanogaster to estimate genetic variation within natural populations.

STUDIES OF LINKAGE IN POPULATIONS. VII. TEMPORAL VARIATION AND X‐CHROMOSOMAL LINKAGE DISEQUILIBRIUMS

  • M. Levitan
  • Biology
    Evolution; international journal of organic evolution
  • 1973
This paper reanalyzes data, presents results from several additional localities, and examines the possibility that the seasonal samples themselves evidence disequilibriums and, if so, whether their nature are attributable to the fluctuations in the linkage combinations described by Levitan (1973).

WHY DOES THE GENOTYPE NOT CONGEAL?

  • J. Turner
  • Biology
    Evolution; international journal of organic evolution
  • 1967
I have tried to combine the various approaches to the problem of two interacting loci into a single model, mostly without explicit equations, in which Fisher's proof is confirmed; increased linkage is always favored provided that the population is at a stable equilibrium or under particular conditions of change; although sometimes when the population was changing under natural selection, it is looser linkage which is favored.

The Genomic Complexity of a Large Inversion in Great Tits

A large inversion polymorphism in the great tit (Parus major) that encompasses almost 1,000 genes and more than 90% of Chromosome 1A is identified, widespread among distinct great tit populations and future studies of the inversion haplotype, including how it affects the fitness of carriers, may help to understand the mechanisms that maintain it.

Modification of linkage intensity by natural selection.

It is suggested that the presence of pail-s of factors in the same chromosome, the selective advantage of each of which reverses that of the other, will always tend to diminish recombination, and therefore, to increase the intensity of linkage in the chromosomes of that species.

ALLOZYME LINKAGE DISEQUILIBRIA AMONG CHROMOSOME COMPLEXES IN THE PERMANENT TRANSLOCATION HETEROZYGOTE OENOTHERA BIENNIS

Among sexual organisms the permanent translocation heterozygotes of the plant genus Oenothera provide the most extreme model system for investigating the genetic consequences of structural hybridity.
...

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