Corpus ID: 39109715

THE EFFECTS OF ADRENERGIC BLOCKING AGENTS AND THEOPHYLLINE ON 3',5'-AMP-INDUCED HYPERGLYCEMIA.

@article{Northrop1964THEEO,
  title={THE EFFECTS OF ADRENERGIC BLOCKING AGENTS AND THEOPHYLLINE ON 3',5'-AMP-INDUCED HYPERGLYCEMIA.},
  author={Gretajo Northrop and R. E. Jun. Parks},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1964},
  volume={145},
  pages={
          87-91
        }
}
  • Gretajo Northrop, R. E. Jun. Parks
  • Published 1964
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • Pretreatment of intact rats with theophylline has been shown to potentiate 3', 5'-AMP-induced hyperglycemia. Administration of 1.0 mg/kg of the cyclic nucleotide, a dose insufficient to cause elevation of blood glucose, has been shown to cause significant hyperglycemia following pretreatment with theophylline (75 mg/kg). Epinephrine and 3', 5'-AMP-induced hyperglycemia are prevented by pretreatment with the adrenergic blocking agent, dihydroergotamine (DHE) (5.6 mg/kg). Hyperglycemia in… CONTINUE READING