Corpus ID: 19825999

THE EFFECT OF COX-2 SPECIFIC INHIBITORS ON FRACTURE HEALING IN THE ADULT RAT FEMUR

@inproceedings{Brown2002THEEO,
  title={THE EFFECT OF COX-2 SPECIFIC INHIBITORS ON FRACTURE HEALING IN THE ADULT RAT FEMUR},
  author={Karen M. Brown and Marnie M. Saunders and Abigail K. Lynn and David C. Goodspeed and Thorsten Kirsch and Henry J. Donahue and J Spence Reid},
  year={2002}
}
Introduction: Numerous studies have demonstrated that administration of non-steroidal anti-inflammatory medications (NSAIDs) results in delayed healing and decreased strength of post -fracture bone (1-3). Many orthopaedists hesitate to prescribe or continue anti-inflammatory medications for fracture or postoperative pain control due to this putative inhibitory effect. Recently, COX-2 specific inhibitors have shown equivalent analgesic efficacy vs. conventional NSAIDs with fewer unwanted side… Expand
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Cox-2 Selective Inhibitors and Bone
TLDR
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely prescribed medications for relief of pain and inflammation but whether COX-2 inhibitors and non-selective NSAIDs lead to clinically relevant adverse effects on bone healing in humans is unknown. Expand