THE DISTRIBUTION OF COLONY-FORMING CELLS AMONG SPLEEN COLONIES.

@article{Siminovitch1963THEDO,
  title={THE DISTRIBUTION OF COLONY-FORMING CELLS AMONG SPLEEN COLONIES.},
  author={L. Siminovitch and E. Mcculloch and J. Till},
  journal={Journal of cellular and comparative physiology},
  year={1963},
  volume={62},
  pages={
          327-36
        }
}
  • L. Siminovitch, E. Mcculloch, J. Till
  • Published 1963
  • Biology, Medicine
  • Journal of cellular and comparative physiology
  • Progenitor cells that are recognized by their ability to form colonies of descendants in the spleens of irradiated mice have the capacity for self-renewal. The distribution of new colony-forming cells per colony is extremely heterogeneous, indicating lax control of self-renewal. The capacities of colony-forming cells for self-renewal, for extensive proliferation, and for giving rise to differentiated descendants, fulfill three requirements for studies of stem cells. Thus, colony-forming cells… CONTINUE READING
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