• Corpus ID: 85688154

THE DENDRITIC CELL AND ITS ROLE IN IMMUNOGENICITY SYSTEM

@inproceedings{Steinman1991THEDC,
  title={THE DENDRITIC CELL AND ITS ROLE IN IMMUNOGENICITY SYSTEM},
  author={Ralph M. Steinman},
  year={1991}
}
Dendritic cells are a system of antigen presenting cells that function to initiate several immune responses such as the sensitization of MHC-restricted T cells, the rejection of organ transplants, and the formation of Tdependent antibodies. Dendritic cells are found in many nonlymphoid tissues but can migrate via the afferent lymph or the blood stream to the T-dependent areas of lymphoid organs. In skin, the immunostimulatory function of dendritic cells is enhanced by cytokines, especially GM… 
Antigen presentation to cytotoxic T lymphocytes in vivo
  • M. Bevan
  • Chemistry, Medicine
    The Journal of experimental medicine
  • 1995
TLDR
An understanding is provided of how CD4 + helper responses can be directed at extracellular antigens while CD8 + cytotoxic responsesCan be directed against intracellular antIGens while T cell priming is understood.
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TLDR
The possibility of transducing dendritic and macrophage progenitors present in the CD34+ cell population and in using a marker gene such as nlsLacZ to study gene expression in antigen presenting cell compartments is set out.
Hepatic dendritic cells: immunobiology and role in liver transplantation
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The reduced ability of cord DCs to attain a fully mature adult phenotype, and to activate naive CD4+ T cells to produce IFN‐γ, suggests that they are intrinsically preprogrammed against the generation of Th‐1 immune responses.
Sustained Expression of CD154 (CD40L) and Proinflammatory Cytokine Production by Alloantigen-Stimulated Umbilical Cord Blood T Cells1
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The data suggest that MDDC-stimulated CB T cells express functional CD154 and provide enough costimulation for dendritic cells to prime naive CD8+CB T cells and induce type 1 cytokine production.
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Spleen macrophages are of major importance as scavenger cells during MHV‐A59 infection and are involved in clearance of virus from the host and may be involved in the regulation of acquired immune responses.
An update on GM-CSF and its potential role in melanoma management
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Intrathymic and Extrathymic Tolerance in Bone Marrow Chimeras
TLDR
It would appear that many of the host-reactive CTL precursors generated in the thymus of chimeras undergo tolerance induction (deletion or irreversible inactivation) in the post-thymic environment, and these cells are rendered "semi-tolerant".
Investigation upon the phenotypic modulation of histiocytic cells
TLDR
The aims of the present study were to analyze the expression of cell surface molecules in different passages of DH82 cells to identify possible inter-passage variances which might be crucial to interpretation and transferability of the results to in vivo mechanisms, and to determine the expression and distribution of cortactin, an important molecule needed for cell migration, in DH 82 cells with or without persistent canine distemper virus infection.
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