THE CRYSTAL STRUCTURE OF A VOLTAGE-GATED SODIUM CHANNEL

@article{Payandeh2011THECS,
  title={THE CRYSTAL STRUCTURE OF A VOLTAGE-GATED SODIUM CHANNEL},
  author={Jian Payandeh and Todd Scheuer and Ning Zheng and William A. Catterall},
  journal={Nature},
  year={2011},
  volume={475},
  pages={353 - 358}
}
Voltage-gated sodium (NaV) channels initiate electrical signalling in excitable cells and are the molecular targets for drugs and disease mutations, but the structural basis for their voltage-dependent activation, ion selectivity and drug block is unknown. Here we report the crystal structure of a voltage-gated Na+ channel from Arcobacter butzleri (NavAb) captured in a closed-pore conformation with four activated voltage sensors at 2.7 Å resolution. The arginine gating charges make multiple… 

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