THE CRITICAL ROLE OF CHLORIDE IN THE CORRECTION OF HYPOKALEMIC ALKALOSIS IN MAN.

@article{Kassirer1965THECR,
  title={THE CRITICAL ROLE OF CHLORIDE IN THE CORRECTION OF HYPOKALEMIC ALKALOSIS IN MAN.},
  author={Jerome P. Kassirer and P M Berkman and D R Lawrenz and W B Schwartz},
  journal={The American journal of medicine},
  year={1965},
  volume={38},
  pages={
          172-89
        }
}
Correction of metabolic alkalosis by the kidney after isomertric expansion of extracellular fluid.
  • J. Cohen
  • Biology
    The Journal of clinical investigation
  • 1968
TLDR
It is suggested that isometric expansion during metabolic alkalosis causes a decrease in proximal sodium reabsorption that relinquishes filtrate to a more distal site in the nephron and that this site may retain chloride preferentially when hypochloremia or chloride deficiency is present.
Aldosterone in metabolic alkalosis.
TLDR
The findings suggest that "saline-resistant" alkalosis, when it occurs in the absence of primary hyperadrenalism, cannot be attributed to aldosterone excess and/or potassium depletion of the magnitude seen in the study.
Dietary NaCl determines severity of potassium depletion-induced metabolic alkalosis.
TLDR
A significantly more severe alkalosis in the Low NaCl Group was evident at all degrees of K+ deficiency achieved during the course of the 15 days of K+.
Role of chloride in metabolic acidosis.
  • T. Wada
  • Medicine
    The Keio journal of medicine
  • 1968
TLDR
The author studied the behavior of the excessive chloride administered and found that isotonic saline does not intensify acidosis, and even that it tends to correct acidosis.
The generation and maintenance of metabolic alkalosis
TLDR
The present paper will be concerned with the factors involved in the generation and maintenance of metabolic alkalosis, andPhysiologic determinants will be explored and clinical derangements will be examined.
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