Corpus ID: 77025673

THE CLINICAL PHARMACOKINETIC STUDIES OF TETRAMETHYLPYRAZINE HYDROCHLORIDE IN NORMAL VOLUNTEERS AND PATIENTS WITH ACUTE CEREBRAL ISCHEMIA DISEASE (CID)

@inproceedings{Xiao1991THECP,
  title={THE CLINICAL PHARMACOKINETIC STUDIES OF TETRAMETHYLPYRAZINE HYDROCHLORIDE IN NORMAL VOLUNTEERS AND PATIENTS WITH ACUTE CEREBRAL ISCHEMIA DISEASE (CID)},
  author={Liu Xiao},
  year={1991}
}
  • Liu Xiao
  • Published 1991
  • Medicine
  • Tetramethylpyrazine(TMPZ). a pure alkaloid isolated fromtraditional Chinese herb, Ligustium Wellichii Franchet, has been widelyused in the treatment of patients with cerebral ischemia disease in ourcountry since 70 's. In this paper, the clinical pharmacokinetics of tetr-amethylpyrazine in normal volunteers (im) and patients with CID (iv. inf)and the plasma protein binding of TMPZ in human and rabbits were stu-died. The results showed that the concentration-time curves mainly fittedto two… CONTINUE READING

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