THE ANTIVIRAL EFFECT OF GUANIDINE AND ITS DERIVATIVES. IV

@article{Ueda1964THEAE,
  title={THE ANTIVIRAL EFFECT OF GUANIDINE AND ITS DERIVATIVES. IV},
  author={T. Ueda and D. Ph. and S. Toyoshima and M. Furukawa and Y. Seto},
  journal={Chemotherapy},
  year={1964},
  volume={12},
  pages={148-152}
}
Our group1,2, RIGHTSEL, et a.13. CROWTHER and MELNICK4 and TAMM and EGGERS5 reported independently that guanidine inhibits the multiplication of poliomyelitis virus in tissue culture and the effect probably is due to the inhibition of intracellular viral replication. Guanidine, however, has a rather small chemotherapeutic index and when doses over 30 mg/kg/day of guanidine are administered to human beings, such side effects as rash and paralysis are observed6. Thus, more effective and less… Expand