THC inhibits the expression of ethanol-induced locomotor sensitization in mice.

@article{Filev2017THCIT,
  title={THC inhibits the expression of ethanol-induced locomotor sensitization in mice.},
  author={Renato Filev and Douglas Senna Engelke and Dartiu Xavier da Silveira and Luiz E Mello and Jair Guilherme Santos-Junior},
  journal={Alcohol},
  year={2017},
  volume={65},
  pages={
          31-35
        }
}
The motivational circuit activated by ethanol leads to behavioral changes that recruit the endocannabinoid system (ECS). Case reports and observational studies suggest that the use of Cannabis sp. mitigates problematic ethanol consumption in humans. Here, we verified the effects of the two main phytocannabinoid compounds of Cannabis sp., cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC), in the expression of ethanol-induced locomotor sensitization in mice. Male adult DBA/2 mice were… CONTINUE READING
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