THC: moderation during implantation

@article{Piomelli2004THCMD,
  title={THC: moderation during implantation},
  author={Daniele Piomelli},
  journal={Nature Medicine},
  year={2004},
  volume={10},
  pages={19-20}
}
Endogenous marijuana-like compounds regulate implantation during pregnancy by activating cannabinoid receptors on the embryo's surface. A new study explores the dynamics of this process and renews concerns about marijuana use in pregnant women. 
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Cannabinoid/Endocannabinoid signaling impact on early pregnancy events.
TLDR
This review summarizes some aspects of cannabinoid/endocannabinoid signaling molecules in preimplantation and implantation biology utilizing genetically engineered mouse models.
Regulation of female fertility by the endocannabinoid system
TLDR
This review will present endocannabinoids, their target receptors and metabolic enzymes, and will discuss the involvement of these bioactive lipids in female mammalian reproduction.
Endocannabinoid signaling directs periimplantation events
TLDR
This review focuses on various aspects of endocannabinoid signaling in preimplantation embryo development and activation, and uterine differentiation during the periIMplantation embryouterine dialog to lead to potential clinical applications of the endoc cannabinoidoid system as a target for regulating female fertility.
CB2 receptors in reproduction
  • M. Maccarrone
  • Biology, Medicine
    British journal of pharmacology
  • 2008
TLDR
This review will focus on the involvement of type‐2 cannabinoid (CB2) receptors in reproductive biology, covering both the male and female sides, and it is hoped that CB2‐dependent endocannabinoid signalling might become a useful target for correcting infertility, in both men and women.
Regulation of male fertility by the endocannabinoid system
The role of sex steroid hormones, cytokines and the endocannabinoid system in female fertility.
TLDR
It is suggested that tight control of the endocannabinoid-hormone-cytokine network is required for successful implantation and early pregnancy maintenance and any defect in such a network may result in foetal loss.
A cannabinoid analogue of Delta9-tetrahydrocannabinol disrupts neural development in chick.
TLDR
The results indicate that the administration of the cannabinoid O-2545 during early embryogenesis results in embryotoxic effects and serves to illuminate the risks of marijuana exposure during the second week of pregnancy, a time point at which most women are unaware of their pregnancies.
Effects of feeding a source of omega-3 fatty acid during the early postpartum period on the endocannabinoid system in the bovine endometrium.
The endocannabinoid 2-arachidonoylglycerol promotes sperm developement through activation of cannabinoid-2 receptors
TLDR
It is found that an autocrine endocannabinoid signalling might be operational during spermatogenesis, and that the ECS is modulated during meiosis, with the levels of the endoc cannabinoidoid 2-arachidonoylglycerol peaking before meiosis.
The Effect of Anandamide on Uterine Nitric Oxide Synthase Activity Depends on the Presence of the Blastocyst
TLDR
AEA levels close to and at implantation sites seems to modulate NOS activity and thus nitric oxide production, fundamental for implantation, via cannabinoid receptors, which depends on the presence of the blastocyst.
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