TH2 cytokines from malignant cells suppress TH1 responses and enforce a global TH2 bias in leukemic cutaneous T-cell lymphoma.

@article{Guenova2013TH2CF,
  title={TH2 cytokines from malignant cells suppress TH1 responses and enforce a global TH2 bias in leukemic cutaneous T-cell lymphoma.},
  author={Emmanuella Guenova and Rei Watanabe and Jessica E. Teague and Jennifer A Desimone and Y Jiang and Mitra Dowlatshahi and Christoph Schlapbach and Knut Schaekel and Alain H. Rook and Marianne Tawa and David C. Fisher and Thomas S Kupper and Rachael A Clark},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2013},
  volume={19 14},
  pages={3755-63}
}
PURPOSE In leukemic cutaneous T-cell lymphoma (L-CTCL), malignant T cells accumulate in the blood and give rise to widespread skin inflammation. Patients have intense pruritus, increased immunoglobulin E (IgE), and decreased T-helper (TH)-1 responses, and most die from infection. Depleting malignant T cells while preserving normal immunity is a clinical challenge. L-CTCL has been variably described as a malignancy of regulatory, TH2 and TH17 cells. EXPERIMENTAL DESIGN We analyzed phenotype… CONTINUE READING

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