TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.

@article{Mosmann1989TH1AT,
  title={TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.},
  author={Timothy R. Mosmann and Robert Lee Coffman},
  journal={Annual review of immunology},
  year={1989},
  volume={7},
  pages={
          145-73
        }
}
Effector functions in the immune system are carried out by a variety of cell types, and as our understanding of the complexity of the system expands, the number of recognized subdivisions of cell types also continues to increase. B lymphocytes, producing antibody, were initially distinguished from T lymphocytes, which provide help for B cells (1, 2). The T-cell population was further divided when surface markers allowed separation of helper cells from cytotoxic cells (3). Although there were… CONTINUE READING

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